KCNJ5

Gene Information

Official Symbol: KCNJ5
Official Name: potassium inwardly rectifying channel subfamily J member 5
Aliases and Previous Symbols: N/A
Entrez ID: 3762
UniProt: P48544
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an integral membrane protein which belongs to one of seven subfamilies of inward-rectifier potassium channel proteins called potassium channel subfamily J. The encoded protein is a subunit of the potassium channel which is homotetrameric. It is controlled by G-proteins and has a greater tendency to allow potassium to flow into a cell rather than out of a cell. Naturally occurring mutations in this gene are associated with aldosterone-producing adenomas. [provided by RefSeq, Aug 2017].
UniProt Summary: This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by external barium. {ECO:0000269|PubMed:22315453, ECO:0000269|PubMed:22628607, ECO:0000269|PubMed:24037882, ECO:0000269|PubMed:27099398, ECO:0000269|PubMed:27293068}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7830
Expression level (log2 read counts): 2.59

Expression Distribution

Screen	Score
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	-1.82
UM0011500 5μM R05 exp245	1.75

voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization
G-protein activated inward rectifier potassium channel activity
atrial cardiac muscle cell membrane repolarization
membrane repolarization during atrial cardiac muscle cell action potential
membrane repolarization during ventricular cardiac muscle cell action potential
ventricular cardiac muscle cell membrane repolarization
voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
atrial cardiac muscle cell to AV node cell signaling
atrial cardiac muscle cell action potential
atrial cardiac muscle cell to AV node cell communication
cardiac muscle cell membrane repolarization
membrane repolarization during cardiac muscle cell action potential
membrane repolarization during action potential
inward rectifier potassium channel activity
ventricular cardiac muscle cell action potential
membrane repolarization
cell-cell signaling involved in cardiac conduction
regulation of heart rate by cardiac conduction
cardiac muscle cell action potential involved in contraction
cardiac muscle cell contraction
T-tubule
potassium ion import across plasma membrane
cell communication involved in cardiac conduction
cardiac muscle cell action potential
inorganic ion import across plasma membrane
inorganic cation import across plasma membrane
cardiac muscle contraction
voltage-gated potassium channel complex
heart contraction
actin-mediated cell contraction
cardiac conduction
action potential
import across plasma membrane
regulation of heart rate
heart process
striated muscle contraction
actin filament-based movement
multicellular organismal signaling
potassium ion transmembrane transport
potassium ion transport