KHK

Entrez Summary: This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. {ECO:0000269|PubMed:12941785}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
∆-9-Tetrahydrocannabinol 30μM R08 exp445	-1.77
CCT251545 0.2μM R06 exp271	1.76
GSK-J4 1μM R07 exp362	1.9

ketohexokinase activity
carbohydrate kinase activity
fructose catabolic process to hydroxyacetone phosphate and glyceraldehyde-3-phosphate
fructose catabolic process
response to disaccharide
response to sucrose
glyceraldehyde-3-phosphate metabolic process
response to fructose
fructose metabolic process
carbohydrate phosphorylation
regulation of glycogen metabolic process
regulation of polysaccharide metabolic process
hexose catabolic process
response to zinc ion
cellular aldehyde metabolic process
monosaccharide catabolic process
regulation of glucose metabolic process
carbohydrate catabolic process
response to glucose
regulation of cellular carbohydrate metabolic process
response to hexose
response to monosaccharide
hexose metabolic process
regulation of generation of precursor metabolites and energy
cellular carbohydrate metabolic process
response to carbohydrate
monosaccharide metabolic process
regulation of carbohydrate metabolic process
response to insulin
response to metal ion
response to peptide hormone
regulation of small molecule metabolic process
small molecule catabolic process
response to peptide
carbohydrate metabolic process
response to inorganic substance
organophosphate metabolic process
response to hormone
response to organonitrogen compound
carbohydrate derivative metabolic process