KPNA1

Entrez Summary: N/A
UniProt Summary: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non- classical NLS.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
PFI-3 10μM R03 exp144	-1.81
NFN1 0.4μM R03 exp99	1.78
NN-Diethyl-meta-toluamide 500μM R08 exp438	1.95
Trimetrexate 0.03μM R08 exp535	1.96
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	2.22
Dynasore 10μM R04 exp180	2.7

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

IBB
Arm

postsynapse to nucleus signaling pathway
apoptotic DNA fragmentation
NLS-bearing protein import into nucleus
modulation by virus of host cellular process
nuclear import signal receptor activity
DNA catabolic process, endonucleolytic
apoptotic nuclear changes
nuclear localization sequence binding
modulation by symbiont of host cellular process
cellular component disassembly involved in execution phase of apoptosis
DNA catabolic process
modulation by virus of host morphology or physiology
postsynaptic signal transduction
modification by symbiont of host morphology or physiology
execution phase of apoptosis
intracellular transport of virus
host cell
transport of virus
multi-organism transport
multi-organism localization
nuclear pore
protein import into nucleus
regulation of DNA recombination
modification of morphology or physiology of other organism involved in symbiotic interaction
import into nucleus
protein import
modification of morphology or physiology of other organism
interaction with host
protein localization to nucleus
viral life cycle
postsynaptic density
nucleocytoplasmic transport
nuclear transport
nucleic acid phosphodiester bond hydrolysis
glutamatergic synapse
regulation of DNA metabolic process
nucleobase-containing compound catabolic process
cellular component disassembly
dendrite
establishment of protein localization to organelle