KPNA2

Entrez Summary: N/A
UniProt Summary: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 4/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	1/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	2/15
prostate	1/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

IBB
Arm

extrinsic component of postsynaptic specialization membrane
entry of viral genome into host nucleus through nuclear pore complex via importin
viral penetration into host nucleus
multi-organism nuclear import
multi-organism intracellular transport
multi-organism cellular localization
postsynapse to nucleus signaling pathway
NLS-bearing protein import into nucleus
modulation by virus of host cellular process
nuclear import signal receptor activity
nuclear localization sequence binding
modulation by symbiont of host cellular process
modulation by virus of host morphology or physiology
postsynaptic signal transduction
modification by symbiont of host morphology or physiology
intracellular transport of virus
host cell
transport of virus
positive regulation of viral life cycle
multi-organism localization
multi-organism transport
protein import into nucleus
regulation of DNA recombination
positive regulation of viral process
modification of morphology or physiology of other organism involved in symbiotic interaction
histone deacetylase binding
import into nucleus
protein import
regulation of viral life cycle
modification of morphology or physiology of other organism
interaction with host
protein localization to nucleus
viral life cycle
regulation of viral process
regulation of symbiosis, encompassing mutualism through parasitism
nucleocytoplasmic transport
nuclear transport
glutamatergic synapse
regulation of DNA metabolic process
establishment of protein localization to organelle