LRCH1

Gene Information
  • Official Symbol: LRCH1
  • Official Name: leucine rich repeats and calponin homology domain containing 1
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 23143
  • UniProt: Q9Y2L9
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a protein with a leucine-rich repeat and a calponin homology domain. Polymorphism in this gene may be associated with susceptibililty to knee osteoarthritis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2010].
  • UniProt Summary: Acts as a negative regulator of GTPase CDC42 by sequestering CDC42-guanine exchange factor DOCK8. Probably by preventing CDC42 activation, negatively regulates CD4(+) T-cell migration. {ECO:0000269|PubMed:28028151}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 4958
  • Expression level (log2 read counts): 4.77

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1