LTC4S

Entrez Summary: The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family includes a number of human proteins, several of which are involved the production of leukotrienes. This gene encodes an enzyme that catalyzes the first step in the biosynthesis of cysteinyl leukotrienes, potent biological compounds derived from arachidonic acid. Leukotrienes have been implicated as mediators of anaphylaxis and inflammatory conditions such as human bronchial asthma. This protein localizes to the nuclear envelope and adjacent endoplasmic reticulum. [provided by RefSeq, Jul 2008].
UniProt Summary: Catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

leukotriene-C4 synthase activity
lipoxin metabolic process
lipoxin biosynthetic process
lipoxygenase pathway
leukotriene biosynthetic process
glutathione peroxidase activity
nuclear outer membrane
glutathione transferase activity
long-chain fatty acid biosynthetic process
leukotriene metabolic process
unsaturated fatty acid biosynthetic process
icosanoid biosynthetic process
enzyme activator activity
cellular oxidant detoxification
fatty acid derivative biosynthetic process
cellular detoxification
unsaturated fatty acid metabolic process
icosanoid metabolic process
long-chain fatty acid metabolic process
fatty acid biosynthetic process
detoxification
lipid binding
fatty acid derivative metabolic process
nuclear envelope
monocarboxylic acid biosynthetic process
cellular response to toxic substance
carboxylic acid biosynthetic process
organic acid biosynthetic process
fatty acid metabolic process
response to toxic substance
monocarboxylic acid metabolic process
lipid biosynthetic process
small molecule biosynthetic process
intracellular membrane-bounded organelle
carboxylic acid metabolic process
endoplasmic reticulum membrane
cellular lipid metabolic process
oxoacid metabolic process
endoplasmic reticulum
organic acid metabolic process