MAGI2
Gene Information
- Official Symbol: MAGI2
- Official Name: membrane associated guanylate kinase, WW and PDZ domain containing 2
- Aliases and Previous Symbols: N/A
- Entrez ID: 9863
- UniProt: Q86UL8
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene interacts with atrophin-1. Atrophin-1 contains a polyglutamine repeat, expansion of which is responsible for dentatorubral and pallidoluysian atrophy. This encoded protein is characterized by two WW domains, a guanylate kinase-like domain, and multiple PDZ domains. It has structural similarity to the membrane-associated guanylate kinase homologue (MAGUK) family. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| Guanylate kin |
| PDZ |
| WW |
GO Terms
| type II activin receptor binding |
| beta-1 adrenergic receptor binding |
| neuroligin clustering involved in postsynaptic membrane assembly |
| planar cell polarity pathway involved in axis elongation |
| positive regulation of synaptic vesicle clustering |
| regulation of synaptic vesicle clustering |
| slit diaphragm |
| glomerular visceral epithelial cell development |
| glomerular epithelial cell development |
| negative regulation of activin receptor signaling pathway |
| nerve growth factor signaling pathway |
| postsynaptic membrane assembly |
| renal filtration cell differentiation |
| glomerular visceral epithelial cell differentiation |
| mitotic cell cycle arrest |
| glomerular epithelial cell differentiation |
| postsynapse assembly |
| glomerular epithelium development |
| positive regulation of phosphoprotein phosphatase activity |
| receptor signaling complex adaptor activity |
| regulation of activin receptor signaling pathway |
| positive regulation of receptor internalization |
| axis elongation |
| neurotrophin signaling pathway |
| postsynaptic membrane organization |
| epithelial cell differentiation involved in kidney development |
| positive regulation of phosphatase activity |
| membrane assembly |
| membrane biogenesis |
| cell differentiation involved in kidney development |
| positive regulation of protein dephosphorylation |
| negative regulation of protein kinase B signaling |
| receptor clustering |
| cellular response to nerve growth factor stimulus |
| phosphatase binding |
| glomerulus development |
| positive regulation of receptor-mediated endocytosis |
| response to nerve growth factor |
| SMAD binding |
| regulation of receptor internalization |
| SMAD protein signal transduction |
| positive regulation of dephosphorylation |
| localization within membrane |
| postsynapse organization |
| synapse assembly |
| nephron epithelium development |
| Wnt signaling pathway, planar cell polarity pathway |
| regulation of receptor-mediated endocytosis |
| positive regulation of endocytosis |
| protein heterooligomerization |
| regulation of establishment of planar polarity |
| regulation of synaptic vesicle cycle |
| developmental growth involved in morphogenesis |
| negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of phosphoprotein phosphatase activity |
| bicellular tight junction |
| nephron development |
| late endosome |
| kidney epithelium development |
| non-canonical Wnt signaling pathway |
| regulation of protein dephosphorylation |
| cell cycle arrest |
| cell-cell junction |
| regulation of phosphatase activity |
| regulation of morphogenesis of an epithelium |
| epithelial cell development |
| transmembrane receptor protein serine/threonine kinase signaling pathway |
| regulation of endocytosis |
| regulation of dephosphorylation |
| regulation of protein kinase B signaling |
| regulation of transmembrane receptor protein serine/threonine kinase signaling pathway |
| postsynaptic density |
| regulation of animal organ morphogenesis |
| negative regulation of cell migration |
| kidney development |
| synapse |
| synapse organization |
| negative regulation of cell motility |
| positive regulation of neuron projection development |
| renal system development |
| negative regulation of mitotic cell cycle |
| negative regulation of cellular component movement |
| urogenital system development |
| negative regulation of locomotion |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| positive regulation of neuron differentiation |
| positive regulation of cell projection organization |
| developmental growth |
| growth |
| dendrite |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| positive regulation of neurogenesis |
| protein localization to membrane |
| regulation of neuron projection development |
| cellular response to growth factor stimulus |
| negative regulation of intracellular signal transduction |
| protein complex oligomerization |
| response to growth factor |
| positive regulation of nervous system development |
| positive regulation of cell development |
| regulation of vesicle-mediated transport |
| negative regulation of cell cycle |
| protein-containing complex |
| regulation of mitotic cell cycle |
| regulation of neuron differentiation |
| negative regulation of cell population proliferation |
| epithelial cell differentiation |
| regulation of plasma membrane bounded cell projection organization |
| perinuclear region of cytoplasm |
| regulation of cell projection organization |
| enzyme linked receptor protein signaling pathway |
| positive regulation of hydrolase activity |
| regulation of neurogenesis |
| regulation of cell migration |
| membrane organization |
| regulation of cell motility |
| regulation of cellular localization |
| regulation of nervous system development |
| regulation of cell development |
| positive regulation of cell differentiation |
| regulation of locomotion |
| positive regulation of transport |
| regulation of cellular component movement |
| cell cycle process |
| regulation of anatomical structure morphogenesis |
| epithelium development |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of cell cycle |
| positive regulation of cellular component organization |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of signal transduction |
| regulation of hydrolase activity |
| cell cycle |
| negative regulation of cell communication |
| negative regulation of signaling |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| response to endogenous stimulus |
| generation of neurons |
| protein-containing complex assembly |
| cellular protein localization |
| cellular macromolecule localization |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| negative regulation of response to stimulus |
| neurogenesis |
| cell development |
| positive regulation of signal transduction |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| tissue development |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| protein-containing complex subunit organization |
| regulation of transport |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Cincreasin 100μM R08 exp473 | -1.85 |
| TNF-alpha 44ng/ml R08 exp533 | -1.85 |
| Asunaprenir 3μM R07 exp336 | -1.84 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6947
- Expression level (log2 read counts): 1.84
Expression Distribution
MAGI2 Expression in NALM6 Cells: 1.84
