MAS1

Entrez Summary: N/A
UniProt Summary: Receptor for angiotensin 1-7 (By similarity). Acts specifically as a functional antagonist of AGTR1 (angiotensin-2 type 1 receptor), although it up-regulates AGTR1 receptor levels. Positive regulation of AGTR1 levels occurs through activation of the G-proteins GNA11 and GNAQ, and stimulation of the protein kinase C signaling cascade. The antagonist effect on AGTR1 function is probably due to AGTR1 being physically altered by MAS1. {ECO:0000250, ECO:0000269|PubMed:15809376, ECO:0000269|PubMed:16611642}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Ibrutinib 1μM R07 exp372	-2.03
Nicotinamide 2000μM R01 exp50	1.74

angiotensin receptor activity
angiotensin type II receptor activity
angiotensin-activated signaling pathway
positive regulation of inositol phosphate biosynthetic process
protein kinase C signaling
regulation of inositol phosphate biosynthetic process
activation of NF-kappaB-inducing kinase activity
cellular response to angiotensin
positive regulation of alcohol biosynthetic process
response to angiotensin
response to gonadotropin
positive regulation of DNA replication
peptide binding
positive regulation of cellular carbohydrate metabolic process
response to activity
regulation of alcohol biosynthetic process
positive regulation of NIK/NF-kappaB signaling
positive regulation of carbohydrate metabolic process
NIK/NF-kappaB signaling
hippocampus development
regulation of carbohydrate biosynthetic process
regulation of DNA replication
limbic system development
regulation of NIK/NF-kappaB signaling
male gonad development
development of primary male sexual characteristics
positive regulation of small molecule metabolic process
regulation of cellular carbohydrate metabolic process
male sex differentiation
pallium development
regulation of carbohydrate metabolic process
gonad development
development of primary sexual characteristics
telencephalon development
sex differentiation
cellular response to peptide hormone stimulus
cellular response to peptide
activation of protein kinase activity
regulation of inflammatory response
forebrain development