MC3R

Entrez Summary: This gene encodes a G-protein-coupled receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone that is expressed in tissues other than the adrenal cortex and melanocytes. This gene maps to the same region as the locus for benign neonatal epilepsy. Mice deficient for this gene have increased fat mass despite decreased food intake, suggesting a role for this gene product in the regulation of energy homeostasis. Mutations in this gene are associated with a susceptibility to obesity in humans. [provided by RefSeq, Jul 2008].
UniProt Summary: Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. {ECO:0000250|UniProtKB:P33033}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

7TM GPCR Srsx
7tm 1

homoiothermy
melanocyte-stimulating hormone receptor activity
melanocortin receptor activity
locomotor rhythm
neuropeptide binding
circadian behavior
rhythmic behavior
regulation of feeding behavior
temperature homeostasis
sodium ion homeostasis
peptide hormone binding
circadian regulation of gene expression
regulation of behavior
phospholipase C-activating G protein-coupled receptor signaling pathway
regulation of heart rate
adenylate cyclase-activating G protein-coupled receptor signaling pathway
monovalent inorganic cation homeostasis
circadian rhythm
cAMP-mediated signaling
cyclic-nucleotide-mediated signaling
regulation of blood pressure
locomotory behavior
adenylate cyclase-modulating G protein-coupled receptor signaling pathway
regulation of heart contraction
G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
rhythmic process
regulation of blood circulation
multicellular organismal homeostasis
second-messenger-mediated signaling
blood circulation
circulatory system process
behavior
regulation of system process
metal ion homeostasis
cation homeostasis
inorganic ion homeostasis
ion homeostasis
chemical homeostasis
G protein-coupled receptor signaling pathway
integral component of plasma membrane