MDFI

Entrez Summary: N/A
UniProt Summary: Inhibits the transactivation activity of the Myod family of myogenic factors and represses myogenesis. Acts by associating with Myod family members and retaining them in the cytoplasm by masking their nuclear localization signals. Can also interfere with the DNA-binding activity of Myod family members. Plays an important role in trophoblast and chondrogenic differentiation. Regulates the transcriptional activity of TCF7L1/TCF3 by interacting directly with TCF7L1/TCF3 and preventing it from binding DNA. Binds to the axin complex, resulting in an increase in the level of free beta-catenin. Affects axin regulation of the WNT and JNK signaling pathways (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Vinblastine 0.002μM R01 exp60	-2.13
Taxol 0.002μM R01 exp54	-1.97

dorsal/ventral axis specification
trophoblast giant cell differentiation
cytoplasmic sequestering of transcription factor
cytoplasmic sequestering of protein
cell differentiation involved in embryonic placenta development
negative regulation of DNA binding
dorsal/ventral pattern formation
axis specification
embryonic placenta development
embryonic skeletal system morphogenesis
maintenance of protein location
regulation of DNA binding
embryonic skeletal system development
placenta development
negative regulation of DNA-binding transcription factor activity
maintenance of location
negative regulation of binding
negative regulation of Wnt signaling pathway
skeletal system morphogenesis
embryonic organ morphogenesis
transcription factor binding
regionalization
regulation of Wnt signaling pathway
in utero embryonic development
regulation of binding
reproductive structure development
regulation of DNA-binding transcription factor activity
reproductive system development
embryonic organ development
pattern specification process
skeletal system development
embryonic morphogenesis
chordate embryonic development
embryo development ending in birth or egg hatching
developmental process involved in reproduction
negative regulation of transcription by RNA polymerase II
animal organ morphogenesis
embryo development
identical protein binding
negative regulation of molecular function