METTL20

Official Symbol: ETFBKMT
Official Name: electron transfer flavoprotein subunit beta lysine methyltransferase
Aliases and Previous Symbols: N/A
Entrez ID: 254013
UniProt: Q8IXQ9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Entrez Summary: N/A
UniProt Summary: Protein-lysine methyltransferase that selectively trimethylates the flavoprotein ETFB in mitochondria (PubMed:25023281, PubMed:25416781). Thereby, may negatively regulate the function of ETFB in electron transfer from Acyl-CoA dehydrogenases to the main respiratory chain (PubMed:25416781). {ECO:0000269|PubMed:25023281, ECO:0000269|PubMed:25416781}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-2.28
Q15 2.7μM R02 exp79	-1.71

Methyltransf 16
PrmA

regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase
negative regulation of fatty acid beta-oxidation using acyl-CoA dehydrogenase
negative regulation of electron transfer activity
negative regulation of fatty acid beta-oxidation
regulation of electron transfer activity
negative regulation of fatty acid oxidation
regulation of fatty acid beta-oxidation
negative regulation of lipid catabolic process
protein-lysine N-methyltransferase activity
negative regulation of oxidoreductase activity
negative regulation of fatty acid metabolic process
peptidyl-lysine trimethylation
regulation of fatty acid oxidation
regulation of lipid catabolic process
heat shock protein binding
negative regulation of lipid metabolic process
regulation of fatty acid metabolic process
peptidyl-lysine methylation
negative regulation of small molecule metabolic process
regulation of oxidoreductase activity
protein methylation
protein alkylation
regulation of generation of precursor metabolites and energy
regulation of cellular ketone metabolic process
macromolecule methylation
negative regulation of cellular catabolic process
negative regulation of catabolic process
methylation
peptidyl-lysine modification
mitochondrial matrix
regulation of lipid metabolic process
regulation of small molecule metabolic process
protein-containing complex
negative regulation of catalytic activity
regulation of cellular catabolic process
peptidyl-amino acid modification
regulation of catabolic process
negative regulation of molecular function