MMP8

Gene Information

Official Symbol: MMP8
Official Name: matrix metallopeptidase 8
Aliases and Previous Symbols: N/A
Entrez ID: 4317
UniProt: P22894
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015].
UniProt Summary: Can degrade fibrillar type I, II, and III collagens.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Epothilone-D 0.004 to 0.006μM on day4 R05 exp232	-1.83
Pifithrin-alpha 20μM R07 exp390	-1.82
Ibrutinib 1μM R07 exp372	-1.81
Milciclib 2μM R08 exp502	1.99
Hippuristanol 0.12μM R08 exp488	2.28

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18684
Expression level (log2 read counts): -0.84

Expression Distribution

Peptidase M10
PG binding 1
Hemopexin

positive regulation of microglial cell activation
positive regulation of neuroinflammatory response
regulation of microglial cell activation
negative regulation of interleukin-10 production
positive regulation of tumor necrosis factor secretion
positive regulation of macrophage activation
regulation of tumor necrosis factor secretion
regulation of neuroinflammatory response
positive regulation of nitric oxide biosynthetic process
positive regulation of nitric oxide metabolic process
endodermal cell differentiation
collagen catabolic process
endoderm formation
positive regulation of reactive oxygen species biosynthetic process
regulation of interleukin-10 production
regulation of macrophage activation
tertiary granule lumen
positive regulation of DNA binding
regulation of nitric oxide biosynthetic process
specific granule lumen
extracellular matrix disassembly
collagen metabolic process
endoderm development
endopeptidase activity
positive regulation of NIK/NF-kappaB signaling
regulation of reactive oxygen species biosynthetic process
positive regulation of tumor necrosis factor production
positive regulation of tumor necrosis factor superfamily cytokine production
positive regulation of interleukin-6 production
positive regulation of reactive oxygen species metabolic process
metalloendopeptidase activity
regulation of NIK/NF-kappaB signaling
formation of primary germ layer
regulation of DNA binding
positive regulation of cytokine secretion
positive regulation of JNK cascade
positive regulation of inflammatory response
regulation of interleukin-6 production
regulation of tumor necrosis factor production
regulation of tumor necrosis factor superfamily cytokine production