MTMR3

Entrez Summary: N/A
UniProt Summary: Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards phosphatidylinositol 3-phosphate and phosphatidylinositol 3,5-bisphosphate. May also dephosphorylate proteins phosphorylated on Ser, Thr, and Tyr residues (PubMed:10733931). {ECO:0000269|PubMed:10733931, ECO:0000269|PubMed:11676921}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Genistein 15μM R07 exp360	-1.74
A-395N 10μM R05 exp219	1.82

FYVE
Myotub-related

phosphatidylinositol 5-phosphate metabolic process
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity
regulation of phosphatidylinositol dephosphorylation
phosphatidylinositol-3-phosphatase activity
phosphatidylinositol dephosphorylation
phospholipid dephosphorylation
regulation of autophagosome assembly
regulation of vacuole organization
cellular response to glucose starvation
protein serine/threonine phosphatase activity
extrinsic component of membrane
regulation of phospholipid metabolic process
protein phosphatase binding
protein tyrosine phosphatase activity
peptidyl-tyrosine dephosphorylation
phosphatidylinositol biosynthetic process
cellular response to starvation
macroautophagy
phosphatidylinositol metabolic process
regulation of macroautophagy
response to starvation
lipid modification
glycerophospholipid biosynthetic process
regulation of dephosphorylation
protein dephosphorylation
regulation of organelle assembly
glycerolipid biosynthetic process
cellular response to nutrient levels
phospholipid biosynthetic process
process utilizing autophagic mechanism
autophagy
cellular response to extracellular stimulus
glycerophospholipid metabolic process
dephosphorylation
regulation of autophagy
cellular response to external stimulus
phospholipid metabolic process
glycerolipid metabolic process
regulation of lipid metabolic process
response to nutrient levels