MYH14

Entrez Summary: This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-14 (MYO14). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene result in one form of autosomal dominant hearing impairment. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

myosin II filament
myosin II complex
actin-dependent ATPase activity
actomyosin
vocalization behavior
microfilament motor activity
mitochondrion morphogenesis
neuronal action potential
skeletal muscle contraction
multicellular organismal movement
musculoskeletal movement
brush border
transmission of nerve impulse
stress fiber
action potential
striated muscle contraction
actin filament-based movement
actomyosin structure organization
skeletal muscle tissue development
growth cone
skeletal muscle organ development
multicellular organismal signaling
sensory perception of sound
regulation of cell shape
sensory perception of mechanical stimulus
calmodulin binding
actin filament binding
ATPase activity
muscle contraction
striated muscle tissue development
muscle organ development
muscle tissue development
muscle system process
regulation of membrane potential
mitochondrion organization
muscle structure development
regulation of cell morphogenesis
actin cytoskeleton organization
cell part morphogenesis
actin filament-based process