NKX2-2

Entrez Summary: The protein encoded by this gene contains a homeobox domain and may be involved in the morphogenesis of the central nervous system. This gene is found on chromosome 20 near NKX2-4, and these two genes appear to be duplicated on chromosome 14 in the form of TITF1 and NKX2-8. The encoded protein is likely to be a nuclear transcription factor. [provided by RefSeq, Jul 2008].
UniProt Summary: Acts as a transcriptional activator. Required for the maintenance of NEUROD1 expression in the horomone-producing endocrine cells of the pancreas. May be involved in specifying diencephalic neuromeric boundaries, and in controlling the expression of genes that play a role in axonal guidance. Associates with chromatin at the NEUROD1 promoter region. Binds to a subset of consensus elements within the NEUROD1 promoter (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

type B pancreatic cell fate commitment
ventral spinal cord interneuron fate determination
cell fate determination involved in pattern specification
pancreatic A cell fate commitment
pancreatic PP cell fate commitment
pancreatic PP cell differentiation
spinal cord oligodendrocyte cell fate specification
spinal cord oligodendrocyte cell differentiation
glial cell fate specification
oligodendrocyte cell fate commitment
oligodendrocyte cell fate specification
pancreatic A cell differentiation
neuron fate determination
optic nerve development
type B pancreatic cell development
glial cell fate commitment
epithelial cell fate commitment
cell fate commitment involved in pattern specification
ventral spinal cord interneuron fate commitment
ventral spinal cord interneuron differentiation
glandular epithelial cell development
type B pancreatic cell differentiation
enteroendocrine cell differentiation
spinal cord dorsal/ventral patterning
positive regulation of oligodendrocyte differentiation
spinal cord patterning
proximal promoter sequence-specific DNA binding
neuron fate specification
spinal cord motor neuron differentiation
endocrine pancreas development
glandular epithelial cell differentiation
regulation of oligodendrocyte differentiation
cell fate determination
positive regulation of glial cell differentiation
oligodendrocyte development
response to progesterone
ventral spinal cord development
columnar/cuboidal epithelial cell development
cranial nerve development
astrocyte differentiation