OLFM1

Entrez Summary: N/A
UniProt Summary: Contributes to the regulation of axonal growth in the embryonic and adult central nervous system by inhibiting interactions between RTN4R and LINGO1. Inhibits RTN4R-mediated axon growth cone collapse (By similarity). May play an important role in regulating the production of neural crest cells by the neural tube (By similarity). May be required for normal responses to olfactory stimuli (By similarity). {ECO:0000250|UniProtKB:O88998, ECO:0000250|UniProtKB:Q9IAK4}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

OLF
Noelin-1

neuronal signal transduction
atrioventricular valve formation
heart valve formation
atrioventricular valve morphogenesis
atrioventricular valve development
axonal growth cone
cardiac epithelial to mesenchymal transition
positive regulation of epithelial to mesenchymal transition
heart valve morphogenesis
heart valve development
epithelial to mesenchymal transition
cell
regulation of epithelial to mesenchymal transition
regulation of axon extension
regulation of extent of cell growth
perikaryon
mesenchymal cell differentiation
regulation of cell size
regulation of axonogenesis
mesenchyme development
heart morphogenesis
synapse
axon
regulation of cell morphogenesis involved in differentiation
regulation of developmental growth
neuronal cell body
regulation of cellular component size
regulation of cell growth
regulation of cell morphogenesis
regulation of neuron projection development
regulation of anatomical structure size
heart development
cell junction
positive regulation of apoptotic process
positive regulation of programmed cell death
regulation of neuron differentiation
regulation of growth
regulation of plasma membrane bounded cell projection organization
positive regulation of cell death
regulation of cell projection organization