PARP10
Gene Information
- Official Symbol: PARP10
- Official Name: poly(ADP-ribose) polymerase family member 10
- Aliases and Previous Symbols: N/A
- Entrez ID: 84875
- UniProt: Q53GL7
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: May play a role in cell proliferation. May be required for the maintenance of cell cycle progression. {ECO:0000269|PubMed:15674325, ECO:0000269|PubMed:16455663}.
Pfam Domains GO Terms
Pfam Domains
| PARP |
GO Terms
| regulation of chromatin assembly |
| negative regulation of protein K63-linked ubiquitination |
| negative regulation of protein polyubiquitination |
| regulation of chromatin assembly or disassembly |
| protein poly-ADP-ribosylation |
| regulation of protein K63-linked ubiquitination |
| protein auto-ADP-ribosylation |
| protein mono-ADP-ribosylation |
| NAD biosynthesis via nicotinamide riboside salvage pathway |
| protein ADP-ribosylase activity |
| K63-linked polyubiquitin modification-dependent protein binding |
| regulation of protein polyubiquitination |
| NAD+ ADP-ribosyltransferase activity |
| negative regulation of fibroblast proliferation |
| NAD biosynthetic process |
| protein ADP-ribosylation |
| pyridine nucleotide biosynthetic process |
| nicotinamide nucleotide biosynthetic process |
| pyridine nucleotide metabolic process |
| nicotinamide nucleotide metabolic process |
| pyridine-containing compound biosynthetic process |
| pyridine-containing compound metabolic process |
| translesion synthesis |
| oxidoreduction coenzyme metabolic process |
| DNA synthesis involved in DNA repair |
| postreplication repair |
| negative regulation of viral genome replication |
| negative regulation of protein ubiquitination |
| negative regulation of viral life cycle |
| regulation of fibroblast proliferation |
| negative regulation of NF-kappaB transcription factor activity |
| negative regulation of protein modification by small protein conjugation or removal |
| regulation of viral genome replication |
| negative regulation of viral process |
| DNA biosynthetic process |
| coenzyme biosynthetic process |
| regulation of viral life cycle |
| negative regulation of DNA-binding transcription factor activity |
| regulation of chromatin organization |
| regulation of protein ubiquitination |
| regulation of viral process |
| cofactor biosynthetic process |
| negative regulation of multi-organism process |
| regulation of symbiosis, encompassing mutualism through parasitism |
| regulation of protein modification by small protein conjugation or removal |
| nucleotide biosynthetic process |
| nucleoside phosphate biosynthetic process |
| coenzyme metabolic process |
| regulation of chromosome organization |
| regulation of DNA-binding transcription factor activity |
| cofactor metabolic process |
| nucleotide metabolic process |
| nucleoside phosphate metabolic process |
| DNA repair |
| organophosphate biosynthetic process |
| nucleobase-containing small molecule metabolic process |
| negative regulation of protein modification process |
| negative regulation of cell population proliferation |
| intracellular membrane-bounded organelle |
| DNA metabolic process |
| cellular response to DNA damage stimulus |
| regulation of multi-organism process |
| nucleolus |
| organophosphate metabolic process |
| regulation of cellular component biogenesis |
| negative regulation of cellular protein metabolic process |
| nucleobase-containing compound biosynthetic process |
| negative regulation of protein metabolic process |
| negative regulation of molecular function |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| regulation of organelle organization |
| organic cyclic compound biosynthetic process |
| organonitrogen compound biosynthetic process |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| cellular response to stress |
| cellular macromolecule biosynthetic process |
| negative regulation of gene expression |
| small molecule metabolic process |
| macromolecule biosynthetic process |
| regulation of protein modification process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 1/726
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/25 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/15 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/14 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/7 |
| thyroid | 0/2 |
| upper aerodigestive | 1/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 3029
- Expression level (log2 read counts): 5.81
Expression Distribution
PARP10 Expression in NALM6 Cells: 5.81
