PDE4B

Entrez Summary: This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].
UniProt Summary: Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May be involved in mediating central nervous system effects of therapeutic agents ranging from antidepressants to antiasthmatic and anti-inflammatory agents. {ECO:0000269|PubMed:10846163, ECO:0000269|PubMed:15003452}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
CyclicAMP 200μM R08 exp475	-2.01
Cisplatin 0.35μM R06 exp273	2.85

negative regulation of relaxation of cardiac muscle
negative regulation of relaxation of muscle
regulation of relaxation of cardiac muscle
cAMP catabolic process
neutrophil homeostasis
regulation of relaxation of muscle
3,5-cyclic-AMP phosphodiesterase activity
cellular response to epinephrine stimulus
cyclic nucleotide catabolic process
gamma-tubulin complex
regulation of high voltage-gated calcium channel activity
response to epinephrine
cAMP metabolic process
cAMP binding
gamma-tubulin binding
voltage-gated calcium channel complex
positive regulation of interleukin-2 production
excitatory synapse
purine ribonucleotide catabolic process
ribonucleotide catabolic process
regulation of voltage-gated calcium channel activity
regulation of cardiac muscle cell contraction
cyclic nucleotide metabolic process
regulation of actin filament-based movement
purine nucleotide catabolic process
purine-containing compound catabolic process
regulation of interleukin-2 production
positive regulation of interferon-gamma production
nucleotide catabolic process
leukocyte homeostasis
nucleoside phosphate catabolic process
regulation of cardiac muscle contraction
neutrophil chemotaxis
regulation of calcium ion transmembrane transporter activity
granulocyte chemotaxis
regulation of striated muscle contraction
neutrophil migration
regulation of interferon-gamma production
granulocyte migration
cellular response to monoamine stimulus