PDE5A
Gene Information
- Official Symbol: PDE5A
- Official Name: phosphodiesterase 5A
- Aliases and Previous Symbols: N/A
- Entrez ID: 8654
- UniProt: O76074
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: N/A
- UniProt Summary: Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'- GMP (PubMed:9714779, PubMed:15489334). Specifically regulates nitric-oxide-generated cGMP (PubMed:15489334). {ECO:0000269|PubMed:15489334, ECO:0000269|PubMed:9714779}.
Pfam Domains GO Terms
Pfam Domains
| PDEase I |
| GAF |
GO Terms
| positive regulation of oocyte development |
| positive regulation of oogenesis |
| cGMP catabolic process |
| negative regulation of cardiac muscle contraction |
| 3,5-cyclic-nucleotide phosphodiesterase activity |
| negative regulation of striated muscle contraction |
| regulation of oocyte development |
| regulation of oogenesis |
| regulation of nitric oxide mediated signal transduction |
| relaxation of cardiac muscle |
| cyclic nucleotide catabolic process |
| cGMP binding |
| 3,5-cyclic-GMP phosphodiesterase activity |
| cGMP metabolic process |
| relaxation of muscle |
| negative regulation of muscle contraction |
| negative regulation of heart contraction |
| positive regulation of cardiac muscle hypertrophy |
| positive regulation of muscle hypertrophy |
| purine ribonucleotide catabolic process |
| negative regulation of blood circulation |
| ribonucleotide catabolic process |
| cyclic nucleotide metabolic process |
| purine nucleotide catabolic process |
| purine-containing compound catabolic process |
| regulation of cardiac muscle hypertrophy |
| regulation of muscle hypertrophy |
| negative regulation of T cell proliferation |
| nucleotide catabolic process |
| nucleoside phosphate catabolic process |
| negative regulation of mononuclear cell proliferation |
| negative regulation of lymphocyte proliferation |
| regulation of cardiac muscle contraction |
| positive regulation of reproductive process |
| negative regulation of leukocyte proliferation |
| regulation of muscle adaptation |
| regulation of striated muscle contraction |
| nucleobase-containing small molecule biosynthetic process |
| negative regulation of T cell activation |
| negative regulation of leukocyte cell-cell adhesion |
| organophosphate catabolic process |
| negative regulation of lymphocyte activation |
| regulation of T cell proliferation |
| regulation of muscle contraction |
| regulation of reproductive process |
| negative regulation of leukocyte activation |
| negative regulation of cell-cell adhesion |
| carbohydrate derivative catabolic process |
| negative regulation of cell activation |
| regulation of lymphocyte proliferation |
| regulation of mononuclear cell proliferation |
| regulation of leukocyte proliferation |
| regulation of muscle system process |
| regulation of heart contraction |
| positive regulation of MAP kinase activity |
| negative regulation of cell adhesion |
| regulation of blood circulation |
| regulation of leukocyte cell-cell adhesion |
| muscle system process |
| purine ribonucleotide metabolic process |
| regulation of T cell activation |
| ribonucleotide metabolic process |
| purine nucleotide metabolic process |
| ribose phosphate metabolic process |
| positive regulation of protein serine/threonine kinase activity |
| regulation of MAP kinase activity |
| purine-containing compound metabolic process |
| nucleobase-containing compound catabolic process |
| regulation of cell-cell adhesion |
| heterocycle catabolic process |
| cellular nitrogen compound catabolic process |
| negative regulation of immune system process |
| aromatic compound catabolic process |
| nucleotide metabolic process |
| cellular component |
| nucleoside phosphate metabolic process |
| organic cyclic compound catabolic process |
| positive regulation of multi-organism process |
| regulation of lymphocyte activation |
| regulation of protein serine/threonine kinase activity |
| positive regulation of protein kinase activity |
| nucleobase-containing small molecule metabolic process |
| positive regulation of cell development |
| positive regulation of MAPK cascade |
| positive regulation of kinase activity |
| regulation of system process |
| small molecule biosynthetic process |
| regulation of leukocyte activation |
| regulation of cell activation |
| positive regulation of transferase activity |
| negative regulation of cell population proliferation |
| regulation of cell adhesion |
| regulation of MAPK cascade |
| regulation of multi-organism process |
| regulation of protein kinase activity |
| regulation of kinase activity |
| organophosphate metabolic process |
| regulation of cell development |
| positive regulation of cell differentiation |
| regulation of transferase activity |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| carbohydrate derivative metabolic process |
| positive regulation of phosphorylation |
| organonitrogen compound catabolic process |
| nucleobase-containing compound biosynthetic process |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| heterocycle biosynthetic process |
| aromatic compound biosynthetic process |
| negative regulation of multicellular organismal process |
| positive regulation of protein modification process |
| organic cyclic compound biosynthetic process |
| positive regulation of developmental process |
| positive regulation of catalytic activity |
| regulation of protein phosphorylation |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| regulation of cell population proliferation |
| cellular nitrogen compound biosynthetic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| positive regulation of protein metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| cellular catabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| regulation of protein modification process |
| system process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
| Screen | Score |
|---|---|
| Betulinic acid 10 to 15μM on day4 R05 exp222 | 1.8 |
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 6121
- Expression level (log2 read counts): 2.99
Expression Distribution
PDE5A Expression in NALM6 Cells: 2.99
