PEBP1

Entrez Summary: N/A
UniProt Summary: Binds ATP, opioids and phosphatidylethanolamine. Has lower affinity for phosphatidylinositol and phosphatidylcholine. Serine protease inhibitor which inhibits thrombin, neuropsin and chymotrypsin but not trypsin, tissue type plasminogen activator and elastase (By similarity). Inhibits the kinase activity of RAF1 by inhibiting its activation and by dissociating the RAF1/MEK complex and acting as a competitive inhibitor of MEK phosphorylation. {ECO:0000250, ECO:0000269|PubMed:18294816}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
LB-100 2μM R05 exp210	6.71
LB-100 4.1μM R02 exp72	7.03

phosphatidylethanolamine binding
serine-type endopeptidase inhibitor activity
negative regulation of MAPK cascade
negative regulation of endopeptidase activity
negative regulation of peptidase activity
enzyme binding
negative regulation of proteolysis
MAPK cascade
signal transduction by protein phosphorylation
negative regulation of protein phosphorylation
regulation of endopeptidase activity
negative regulation of phosphorylation
regulation of peptidase activity
negative regulation of hydrolase activity
protein kinase binding
negative regulation of intracellular signal transduction
negative regulation of phosphate metabolic process
negative regulation of phosphorus metabolic process
negative regulation of protein modification process
regulation of proteolysis
regulation of MAPK cascade
negative regulation of catalytic activity
protein phosphorylation
negative regulation of cellular protein metabolic process
negative regulation of protein metabolic process
negative regulation of molecular function
negative regulation of signal transduction
regulation of hydrolase activity
phosphorylation
negative regulation of cell communication
negative regulation of signaling
RNA binding
regulation of protein phosphorylation
ATP binding
regulation of phosphorylation
negative regulation of response to stimulus
intracellular signal transduction
regulation of phosphate metabolic process
regulation of phosphorus metabolic process
regulation of intracellular signal transduction