PFKM

Entrez Summary: Three phosphofructokinase isozymes exist in humans: muscle, liver and platelet. These isozymes function as subunits of the mammalian tetramer phosphofructokinase, which catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-bisphosphate. Tetramer composition varies depending on tissue type. This gene encodes the muscle-type isozyme. Mutations in this gene have been associated with glycogen storage disease type VII, also known as Tarui disease. Alternatively spliced transcript variants have been described.[provided by RefSeq, Nov 2009].
UniProt Summary: Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

6-phosphofructokinase complex
6-phosphofructokinase activity
fructose-6-phosphate binding
fructose binding
fructose 1,6-bisphosphate metabolic process
fructose 6-phosphate metabolic process
AMP binding
monosaccharide binding
muscle cell cellular homeostasis
NADH regeneration
glucose catabolic process to pyruvate
canonical glycolysis
glycolytic process through glucose-6-phosphate
glycolytic process through fructose-6-phosphate
glucose catabolic process
NADH metabolic process
glycolytic process
ATP generation from ADP
NAD metabolic process
ADP metabolic process
hexose catabolic process
nucleoside diphosphate phosphorylation
purine ribonucleoside diphosphate metabolic process
nucleotide phosphorylation
monosaccharide catabolic process
purine nucleoside diphosphate metabolic process
ribonucleoside diphosphate metabolic process
pyruvate metabolic process
nucleoside diphosphate metabolic process
kinase binding
protein homotetramerization
glucose metabolic process
carbohydrate catabolic process
protein tetramerization
hexose metabolic process
protein C-terminus binding
monosaccharide metabolic process
ATP metabolic process
purine ribonucleotide metabolic process
apical plasma membrane