PHEX

Entrez Summary: The protein encoded by this gene is a transmembrane endopeptidase that belongs to the type II integral membrane zinc-dependent endopeptidase family. The protein is thought to be involved in bone and dentin mineralization and renal phosphate reabsorption. Mutations in this gene cause X-linked hypophosphatemic rickets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013].
UniProt Summary: Probably involved in bone and dentin mineralization and renal phosphate reabsorption.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/694

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/26
bone	0/26
breast	0/30
central nervous system	0/49
cervix	0/4
colorectal	0/17
esophagus	0/11
fibroblast	0/1
gastric	0/14
kidney	0/18
liver	0/19
lung	0/72
lymphocyte	0/16
ovary	0/25
pancreas	0/22
peripheral nervous system	0/15
plasma cell	0/12
prostate	0/1
skin	0/20
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/28
uterus	0/5

Expression Distribution

Peptidase M13 N
Peptidase M13

response to insulin-like growth factor stimulus
response to sodium phosphate
cellular response to parathyroid hormone stimulus
response to parathyroid hormone
cellular response to vitamin D
response to salt
cellular response to vitamin
response to vitamin D
response to growth hormone
bone mineralization
cellular response to nutrient
response to vitamin
biomineral tissue development
biomineralization
metalloendopeptidase activity
odontogenesis
lung development
respiratory tube development
respiratory system development
bone development
response to nutrient
cellular response to nutrient levels
ossification
cellular response to extracellular stimulus
cellular response to external stimulus
response to peptide hormone
response to peptide
skeletal system development
response to nutrient levels
cellular response to lipid
response to extracellular stimulus
response to inorganic substance
cellular response to organic cyclic compound
cellular response to hormone stimulus
perinuclear region of cytoplasm
zinc ion binding
tube development
response to lipid
organophosphate metabolic process
response to hormone