PI3

Entrez Summary: N/A
UniProt Summary: Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Cementoin
WAP

copulation
structural constituent of epidermis
mating
endopeptidase inhibitor activity
peptide cross-linking
cornified envelope
serine-type endopeptidase inhibitor activity
antimicrobial humoral response
cornification
keratinization
extracellular matrix
negative regulation of endopeptidase activity
negative regulation of peptidase activity
keratinocyte differentiation
epidermal cell differentiation
humoral immune response
negative regulation of proteolysis
skin development
epidermis development
regulation of endopeptidase activity
regulation of peptidase activity
negative regulation of hydrolase activity
epithelial cell differentiation
regulation of proteolysis
negative regulation of catalytic activity
sexual reproduction
multi-organism reproductive process
negative regulation of cellular protein metabolic process
programmed cell death
cell death
negative regulation of protein metabolic process
epithelium development
negative regulation of molecular function
regulation of hydrolase activity
response to other organism
response to external biotic stimulus
response to biotic stimulus
reproductive process
reproduction
tissue development