PLCB1
Gene Information
- Official Symbol: PLCB1
- Official Name: phospholipase C beta 1
- Aliases and Previous Symbols: N/A
- Entrez ID: 23236
- UniProt: Q9NQ66
- Interactions: BioGRID
- PubMed articles: Open PubMed
- OMIM: Open OMIM
Function Summary
- Entrez Summary: The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
- UniProt Summary: N/A
Pfam Domains GO Terms
Pfam Domains
| PLC-beta C |
| efhand like |
| PI-PLC-Y |
| PI-PLC-X |
GO Terms
| positive regulation of CD24 biosynthetic process |
| negative regulation of monocyte extravasation |
| regulation of CD24 biosynthetic process |
| activation of meiosis involved in egg activation |
| regulation of retrograde trans-synaptic signaling by endocanabinoid |
| activation of meiosis |
| regulation of monocyte extravasation |
| egg activation |
| negative regulation of mononuclear cell migration |
| negative regulation of cellular extravasation |
| phospholipase C activity |
| positive regulation of acrosome reaction |
| insulin-like growth factor receptor signaling pathway |
| interleukin-15-mediated signaling pathway |
| cellular response to interleukin-15 |
| positive regulation of fertilization |
| response to interleukin-15 |
| positive regulation of meiotic nuclear division |
| lamin binding |
| inositol trisphosphate biosynthetic process |
| postsynaptic modulation of chemical synaptic transmission |
| G protein-coupled acetylcholine receptor signaling pathway |
| inositol trisphosphate metabolic process |
| regulation of acrosome reaction |
| positive regulation of glycoprotein biosynthetic process |
| positive regulation of glycoprotein metabolic process |
| positive regulation of myoblast differentiation |
| positive regulation of meiotic cell cycle |
| phosphatidylinositol phospholipase C activity |
| inositol phosphate biosynthetic process |
| regulation of fertilization |
| regulation of cellular extravasation |
| acetylcholine receptor signaling pathway |
| regulation of meiotic nuclear division |
| cellular response to acetylcholine |
| response to acetylcholine |
| positive regulation of interleukin-12 production |
| positive regulation of G1/S transition of mitotic cell cycle |
| positive regulation of embryonic development |
| Wnt signaling pathway, calcium modulating pathway |
| postsynaptic signal transduction |
| regulation of glycoprotein biosynthetic process |
| glutamate receptor signaling pathway |
| regulation of glycoprotein metabolic process |
| negative regulation of leukocyte migration |
| regulation of mononuclear cell migration |
| interleukin-12-mediated signaling pathway |
| positive regulation of cell cycle G1/S phase transition |
| cellular response to interleukin-12 |
| response to interleukin-12 |
| regulation of meiotic cell cycle |
| regulation of myoblast differentiation |
| regulation of interleukin-12 production |
| release of sequestered calcium ion into cytosol |
| negative regulation of sequestering of calcium ion |
| inositol phosphate metabolic process |
| polyol biosynthetic process |
| positive regulation of nuclear division |
| GABA-ergic synapse |
| calcium ion transmembrane import into cytosol |
| phosphatidylinositol-mediated signaling |
| calcium ion transport into cytosol |
| inositol lipid-mediated signaling |
| phosphatidylinositol-4,5-bisphosphate binding |
| positive regulation of mitotic cell cycle phase transition |
| positive regulation of reproductive process |
| postsynapse |
| cytosolic calcium ion transport |
| signal transduction involved in cellular response to ammonium ion |
| positive regulation of cell cycle phase transition |
| interleukin-1-mediated signaling pathway |
| fat cell differentiation |
| polyol metabolic process |
| alcohol biosynthetic process |
| cerebral cortex development |
| memory |
| regulation of sequestering of calcium ion |
| regulation of embryonic development |
| cellular response to ammonium ion |
| G2/M transition of mitotic cell cycle |
| cell cycle G2/M phase transition |
| non-canonical Wnt signaling pathway |
| positive regulation of JNK cascade |
| single fertilization |
| regulation of G protein-coupled receptor signaling pathway |
| regulation of G1/S transition of mitotic cell cycle |
| positive regulation of mitotic cell cycle |
| regulation of reproductive process |
| regulation of cell cycle G1/S phase transition |
| positive regulation of stress-activated MAPK cascade |
| phosphatidylinositol metabolic process |
| positive regulation of stress-activated protein kinase signaling cascade |
| fertilization |
| positive regulation of developmental growth |
| pallium development |
| cellular response to interleukin-1 |
| response to ammonium ion |
| regulation of JNK cascade |
| organic hydroxy compound biosynthetic process |
| regulation of nuclear division |
| regulation of leukocyte migration |
| calcium ion transmembrane transport |
| response to interleukin-1 |
| calmodulin binding |
| regulation of stress-activated MAPK cascade |
| regulation of stress-activated protein kinase signaling cascade |
| nuclear chromatin |
| nuclear membrane |
| calcium ion transport |
| telencephalon development |
| negative regulation of cell migration |
| positive regulation of growth |
| learning or memory |
| mitotic cell cycle phase transition |
| negative regulation of cell motility |
| cell cycle phase transition |
| GTPase activator activity |
| positive regulation of cytosolic calcium ion concentration |
| positive regulation of cell cycle process |
| divalent metal ion transport |
| lipid catabolic process |
| cognition |
| divalent inorganic cation transport |
| glycerophospholipid metabolic process |
| negative regulation of cellular component movement |
| alcohol metabolic process |
| negative regulation of locomotion |
| regulation of cytosolic calcium ion concentration |
| regulation of developmental growth |
| glutamatergic synapse |
| enzyme binding |
| Wnt signaling pathway |
| cell-cell signaling by wnt |
| phospholipid metabolic process |
| positive regulation of cell cycle |
| glycerolipid metabolic process |
| forebrain development |
| nuclear speck |
| cellular response to drug |
| regulation of mitotic cell cycle phase transition |
| positive regulation of GTPase activity |
| cell surface receptor signaling pathway involved in cell-cell signaling |
| cellular calcium ion homeostasis |
| modulation of chemical synaptic transmission |
| negative regulation of immune system process |
| regulation of trans-synaptic signaling |
| regulation of cell cycle phase transition |
| positive regulation of cytokine production |
| calcium ion homeostasis |
| organic hydroxy compound metabolic process |
| synaptic signaling |
| cellular divalent inorganic cation homeostasis |
| regulation of GTPase activity |
| divalent inorganic cation homeostasis |
| positive regulation of multi-organism process |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| organophosphate biosynthetic process |
| positive regulation of MAPK cascade |
| cellular metal ion homeostasis |
| inorganic cation transmembrane transport |
| behavior |
| small molecule biosynthetic process |
| protein-containing complex |
| mitotic cell cycle process |
| cellular response to hormone stimulus |
| cation transmembrane transport |
| positive regulation of organelle organization |
| metal ion homeostasis |
| regulation of mitotic cell cycle |
| cellular cation homeostasis |
| metal ion transport |
| cellular ion homeostasis |
| inorganic ion transmembrane transport |
| cellular response to nitrogen compound |
| regulation of growth |
| cytokine-mediated signaling pathway |
| mitotic cell cycle |
| regulation of cytokine production |
| cation homeostasis |
| enzyme linked receptor protein signaling pathway |
| inorganic ion homeostasis |
| calcium ion binding |
| regulation of cellular response to stress |
| brain development |
| cellular chemical homeostasis |
| regulation of cell cycle process |
| regulation of MAPK cascade |
| positive regulation of hydrolase activity |
| regulation of multi-organism process |
| head development |
| ion homeostasis |
| cation transport |
| sexual reproduction |
| regulation of cell migration |
| protein homodimerization activity |
| organophosphate metabolic process |
| cellular homeostasis |
| response to hormone |
| regulation of cell motility |
| ion transmembrane transport |
| cellular lipid metabolic process |
| positive regulation of cell differentiation |
| central nervous system development |
| regulation of locomotion |
| regulation of cellular component movement |
| multi-organism reproductive process |
| cell cycle process |
| cellular response to cytokine stimulus |
| positive regulation of protein phosphorylation |
| positive regulation of intracellular signal transduction |
| response to drug |
| cellular response to oxygen-containing compound |
| positive regulation of phosphorylation |
| cell activation |
| response to nitrogen compound |
| response to cytokine |
| chemical homeostasis |
| cell-cell signaling |
| positive regulation of phosphate metabolic process |
| positive regulation of phosphorus metabolic process |
| regulation of cell cycle |
| negative regulation of transcription, DNA-templated |
| positive regulation of cellular component organization |
| lipid metabolic process |
| cellular response to endogenous stimulus |
| positive regulation of protein modification process |
| negative regulation of nucleic acid-templated transcription |
| negative regulation of RNA biosynthetic process |
| transmembrane transport |
| regulation of hydrolase activity |
| regulation of organelle organization |
| G protein-coupled receptor signaling pathway |
| negative regulation of RNA metabolic process |
| cell cycle |
| positive regulation of developmental process |
| ion transport |
| nervous system process |
| negative regulation of cellular macromolecule biosynthetic process |
| reproductive process |
| reproduction |
| positive regulation of catalytic activity |
| negative regulation of nucleobase-containing compound metabolic process |
| regulation of protein phosphorylation |
| negative regulation of macromolecule biosynthetic process |
| response to endogenous stimulus |
| regulation of response to stress |
| negative regulation of cellular biosynthetic process |
| positive regulation of transcription, DNA-templated |
| negative regulation of biosynthetic process |
| response to oxygen-containing compound |
| regulation of phosphorylation |
| positive regulation of cellular protein metabolic process |
| positive regulation of nucleic acid-templated transcription |
| positive regulation of RNA biosynthetic process |
| homeostatic process |
| positive regulation of signal transduction |
| regulation of immune system process |
| intracellular signal transduction |
| positive regulation of protein metabolic process |
| negative regulation of gene expression |
| positive regulation of RNA metabolic process |
| positive regulation of multicellular organismal process |
| small molecule metabolic process |
| organic substance catabolic process |
| positive regulation of molecular function |
| regulation of phosphate metabolic process |
| regulation of phosphorus metabolic process |
| regulation of cell differentiation |
| positive regulation of cell communication |
| positive regulation of signaling |
| regulation of intracellular signal transduction |
| establishment of localization in cell |
| regulation of protein modification process |
| positive regulation of nucleobase-containing compound metabolic process |
| positive regulation of macromolecule biosynthetic process |
| system process |
| positive regulation of cellular biosynthetic process |
| positive regulation of gene expression |
| positive regulation of biosynthetic process |
CRISPR Data
Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Compound Hit
No hits were found.
Most Correlated Genes in Chemogenomics
No correlation found to any other genes in chemogenomics.
Tissues where Essential in the Avana Dataset (DepMap 20Q1)
Global Fraction of Cell Lines Where Essential: 0/739
| Tissue | Fraction Of Cell Lines Where Essential |
|---|---|
| 1290807.0 | 0/1 |
| 909776.0 | 0/1 |
| bile duct | 0/28 |
| blood | 0/28 |
| bone | 0/26 |
| breast | 0/33 |
| central nervous system | 0/56 |
| cervix | 0/4 |
| colorectal | 0/17 |
| esophagus | 0/13 |
| fibroblast | 0/1 |
| gastric | 0/16 |
| kidney | 0/21 |
| liver | 0/20 |
| lung | 0/75 |
| lymphocyte | 0/16 |
| ovary | 0/26 |
| pancreas | 0/24 |
| peripheral nervous system | 0/16 |
| plasma cell | 0/15 |
| prostate | 0/1 |
| skin | 0/24 |
| soft tissue | 0/9 |
| thyroid | 0/2 |
| upper aerodigestive | 0/22 |
| urinary tract | 0/29 |
| uterus | 0/5 |
Essentiality in NALM6
- Essentiality Rank: 15631
- Expression level (log2 read counts): 4.67
Expression Distribution
PLCB1 Expression in NALM6 Cells: 4.67
