POP1

Entrez Summary: This gene encodes the protein subunit of two different small nucleolar ribonucleoprotein complexes: the endoribonuclease for mitochondrial RNA processing complex and the ribonuclease P complex. The encoded protein is a ribonuclease that localizes to the nucleus and functions in pre-RNA processing. This protein is also an autoantigen in patients suffering from connective tissue diseases. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009].
UniProt Summary: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of RNase MRP.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
SNS-032 25μM R07 exp401	-1.94
Docetaxel 0.002μM R01 exp45	1.71
Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53	1.81
CyclicAMP 200μM R08 exp475	2
Nifurtimox 1μM R03 exp141	2.13
PFI-3 10μM R03 exp144	2.15
YM155 0.0002μM R01 exp61	2.19

Global Fraction of Cell Lines Where Essential: 138/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	1/1
bile duct	7/28
blood	2/28
bone	5/26
breast	1/33
central nervous system	11/56
cervix	1/4
colorectal	5/17
esophagus	1/13
fibroblast	1/1
gastric	0/16
kidney	5/21
liver	5/20
lung	17/75
lymphocyte	2/16
ovary	7/26
pancreas	4/24
peripheral nervous system	7/16
plasma cell	2/15
prostate	0/1
skin	2/24
soft tissue	3/9
thyroid	0/2
upper aerodigestive	5/22
urinary tract	6/29
uterus	1/5

Expression Distribution

POP1
POPLD

ribonuclease MRP activity
nucleolar ribonuclease P complex
ribonuclease MRP complex
tRNA catabolic process
multimeric ribonuclease P complex
ribonuclease P RNA binding
ribonuclease P activity
tRNA 5-leader removal
tRNA 5-end processing
ncRNA 5-end processing
RNA 5-end processing
ncRNA catabolic process
RNA phosphodiester bond hydrolysis, endonucleolytic
tRNA processing
RNA phosphodiester bond hydrolysis
tRNA metabolic process
RNA catabolic process
nucleic acid phosphodiester bond hydrolysis
nucleobase-containing compound catabolic process
ncRNA processing
heterocycle catabolic process
cellular nitrogen compound catabolic process
aromatic compound catabolic process
ncRNA metabolic process
organic cyclic compound catabolic process
nucleolus
RNA processing
cellular macromolecule catabolic process
macromolecule catabolic process
RNA binding
extracellular space
RNA metabolic process
organic substance catabolic process
cellular catabolic process
gene expression