PPIB

Entrez Summary: The protein encoded by this gene is a cyclosporine-binding protein and is mainly located within the endoplasmic reticulum. It is associated with the secretory pathway and released in biological fluids. This protein can bind to cells derived from T- and B-lymphocytes, and may regulate cyclosporine A-mediated immunosuppression. Variants have been identified in this protein that give rise to recessive forms of osteogenesis imperfecta. [provided by RefSeq, Oct 2009].
UniProt Summary: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

regulation of post-translational protein modification
positive regulation by host of viral genome replication
endoplasmic reticulum chaperone complex
modulation by host of viral genome replication
RNA polymerase binding
positive regulation by host of viral process
cyclosporin A binding
smooth endoplasmic reticulum
modulation by host of viral process
positive regulation of multicellular organism growth
positive regulation of viral genome replication
protein refolding
protein peptidyl-prolyl isomerization
peptidyl-prolyl cis-trans isomerase activity
chaperone-mediated protein folding
peptidyl-proline modification
positive regulation of viral life cycle
collagen binding
regulation of multicellular organism growth
modification by host of symbiont morphology or physiology
interaction with symbiont
regulation of viral genome replication
melanosome
positive regulation of viral process
modification of morphology or physiology of other organism involved in symbiotic interaction
unfolded protein binding
regulation of viral life cycle
modification of morphology or physiology of other organism
positive regulation of developmental growth
protein stabilization
bone development
regulation of viral process
regulation of symbiosis, encompassing mutualism through parasitism
protein folding
positive regulation of growth
regulation of protein stability
endoplasmic reticulum lumen
regulation of developmental growth
focal adhesion
skeletal system development