PRODH

Entrez Summary: This gene encodes a mitochondrial protein that catalyzes the first step in proline degradation. Mutations in this gene are associated with hyperprolinemia type 1 and susceptibility to schizophrenia 4 (SCZD4). This gene is located on chromosome 22q11.21, a region which has also been associated with the contiguous gene deletion syndromes, DiGeorge and CATCH22. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010].
UniProt Summary: Converts proline to delta-1-pyrroline-5-carboxylate.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 1/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Dynasore 7μM R08 exp436	1.79
Vincristine 0.0005μM R04 exp190	1.83
NN-Diethyl-meta-toluamide 100μM R05 exp237	1.91

proline dehydrogenase activity
proline catabolic process to glutamate
proline catabolic process
4-hydroxyproline catabolic process
proline metabolic process
4-hydroxyproline metabolic process
intrinsic apoptotic signaling pathway in response to oxidative stress
cell death in response to oxidative stress
glutamine family amino acid catabolic process
cellular modified amino acid catabolic process
glutamate metabolic process
FAD binding
glutamine family amino acid metabolic process
dicarboxylic acid metabolic process
alpha-amino acid catabolic process
cellular amino acid catabolic process
intrinsic apoptotic signaling pathway
cellular modified amino acid metabolic process
alpha-amino acid metabolic process
cellular response to oxidative stress
carboxylic acid catabolic process
organic acid catabolic process
apoptotic signaling pathway
cellular amino acid metabolic process
mitochondrial matrix
response to oxidative stress
mitochondrial inner membrane
heterocycle catabolic process
small molecule catabolic process
organic cyclic compound catabolic process
positive regulation of cell death
carboxylic acid metabolic process
apoptotic process
oxidation-reduction process
oxoacid metabolic process
organic acid metabolic process
programmed cell death
organonitrogen compound catabolic process
cell death
mitochondrion