RASGRP3

Entrez Summary: The protein encoded by this gene is a guanine nucleotide exchange factor that activates the oncogenes HRAS and RAP1A. Defects in this gene have been associated with systemic lupus erythematosus and several cancers. [provided by RefSeq, Mar 2017].
UniProt Summary: N/A

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

guanyl-nucleotide exchange factor complex
diacylglycerol binding
Ras guanyl-nucleotide exchange factor activity
kinase binding
guanyl-nucleotide exchange factor activity
Ras protein signal transduction
GTPase activator activity
small GTPase mediated signal transduction
MAPK cascade
signal transduction by protein phosphorylation
positive regulation of GTPase activity
regulation of GTPase activity
perinuclear region of cytoplasm
calcium ion binding
positive regulation of hydrolase activity
protein phosphorylation
regulation of hydrolase activity
phosphorylation
integral component of plasma membrane
positive regulation of catalytic activity
intracellular signal transduction
positive regulation of molecular function