RFX4

Gene Information

Official Symbol: RFX4
Official Name: regulatory factor X4
Aliases and Previous Symbols: N/A
Entrez ID: 5992
UniProt: Q33E94
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3920
Expression level (log2 read counts): 0.96

Expression Distribution

negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning
spinal cord dorsal/ventral patterning
spinal cord patterning
negative regulation of smoothened signaling pathway
regulation of protein processing
regulation of protein maturation
regulation of smoothened signaling pathway
dorsal/ventral pattern formation
spinal cord development
telencephalon development
negative regulation of nervous system development
regionalization
cilium assembly
cilium organization
forebrain development
pattern specification process
plasma membrane bounded cell projection assembly
DNA-binding transcription activator activity, RNA polymerase II-specific
cell projection assembly
RNA polymerase II proximal promoter sequence-specific DNA binding
DNA-binding transcription factor activity
regulation of proteolysis
brain development
organelle assembly
head development
regulation of nervous system development
negative regulation of developmental process
central nervous system development
plasma membrane bounded cell projection organization
cell projection organization
negative regulation of multicellular organismal process
positive regulation of transcription by RNA polymerase II
negative regulation of signal transduction
negative regulation of cell communication
negative regulation of signaling
positive regulation of transcription, DNA-templated
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of response to stimulus
positive regulation of nucleic acid-templated transcription
positive regulation of RNA biosynthetic process