RGL2

Entrez Summary: N/A
UniProt Summary: Probable guanine nucleotide exchange factor. Putative effector of Ras and/or Rap. Associates with the GTP-bound form of Rap 1A and H-Ras in vitro (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Arsenate 40μM R06 exp264	-2.39
Menadione 5μM R06 exp292	-1.73

regulation of Ral protein signal transduction
Ras guanyl-nucleotide exchange factor activity
negative regulation of cardiac muscle cell apoptotic process
negative regulation of striated muscle cell apoptotic process
negative regulation of muscle cell apoptotic process
regulation of cardiac muscle cell apoptotic process
regulation of striated muscle cell apoptotic process
regulation of muscle cell apoptotic process
Rho guanyl-nucleotide exchange factor activity
positive regulation of phosphatidylinositol 3-kinase signaling
regulation of phosphatidylinositol 3-kinase signaling
regulation of Ras protein signal transduction
Ras protein signal transduction
small GTPase mediated signal transduction
regulation of small GTPase mediated signal transduction
cellular component
negative regulation of apoptotic process
negative regulation of programmed cell death
negative regulation of cell death
positive regulation of intracellular signal transduction
regulation of apoptotic process
regulation of programmed cell death
positive regulation of signal transduction
regulation of cell death
intracellular signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction