RORB

Gene Information

Official Symbol: RORB
Official Name: RAR related orphan receptor B
Aliases and Previous Symbols: N/A
Entrez ID: 6096
UniProt: Q92753
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: The protein encoded by this gene is a member of the NR1 subfamily of nuclear hormone receptors. It is a DNA-binding protein that can bind as a monomer or as a homodimer to hormone response elements upstream of several genes to enhance the expression of those genes. The encoded protein has been shown to interact with NM23-2, a nucleoside diphosphate kinase involved in organogenesis and differentiation, and to help regulate the expression of some genes involved in circadian rhythm. [provided by RefSeq, Feb 2014].
UniProt Summary: Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity). {ECO:0000250}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 17118
Expression level (log2 read counts): 1.18

Expression Distribution

Hormone recep
zf-C4

melatonin receptor activity
amacrine cell differentiation
retinal rod cell development
retinal cone cell differentiation
retinal cone cell development
camera-type eye photoreceptor cell differentiation
eye photoreceptor cell development
negative regulation of osteoblast differentiation
eye photoreceptor cell differentiation
photoreceptor cell development
nuclear receptor activity
retina morphogenesis in camera-type eye
steroid hormone receptor activity
photoreceptor cell differentiation
neural retina development
cellular response to retinoic acid
negative regulation of ossification
response to retinoic acid
regulation of osteoblast differentiation
camera-type eye morphogenesis
regulation of circadian rhythm
steroid hormone mediated signaling pathway
retina development in camera-type eye
eye morphogenesis
intracellular receptor signaling pathway
hormone-mediated signaling pathway
transcription initiation from RNA polymerase II promoter
cellular response to steroid hormone stimulus
regulation of ossification
cellular response to acid chemical
DNA-templated transcription, initiation
visual perception
sensory perception of light stimulus
sensory organ morphogenesis
rhythmic process
camera-type eye development
response to steroid hormone
transcription factor binding
response to acid chemical
eye development