RPF2

Entrez Summary: N/A
UniProt Summary: Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus. {ECO:0000269|PubMed:24120868}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 238/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	0/1
bile duct	11/28
blood	7/28
bone	7/26
breast	8/33
central nervous system	30/56
cervix	3/4
colorectal	4/17
esophagus	5/13
fibroblast	0/1
gastric	6/16
kidney	10/21
liver	4/20
lung	18/75
lymphocyte	7/16
ovary	7/26
pancreas	9/24
peripheral nervous system	4/16
plasma cell	3/15
prostate	0/1
skin	10/24
soft tissue	5/9
thyroid	2/2
upper aerodigestive	4/22
urinary tract	7/29
uterus	2/5

Expression Distribution

protein localization to nucleolus
5S rRNA binding
maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
maturation of LSU-rRNA
ribosomal large subunit assembly
ribosome assembly
ribosomal large subunit biogenesis
protein localization to nucleus
regulation of signal transduction by p53 class mediator
rRNA processing
rRNA metabolic process
ribonucleoprotein complex assembly
ribonucleoprotein complex subunit organization
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
protein localization to organelle
organelle assembly
cellular protein-containing complex assembly
nucleolus
RNA processing
RNA binding
protein-containing complex assembly
cellular protein localization
cellular macromolecule localization
RNA metabolic process
regulation of intracellular signal transduction
protein-containing complex subunit organization
gene expression