RPP40

Entrez Summary: N/A
UniProt Summary: Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 692/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	1/1
909776.0	1/1
bile duct	26/28
blood	25/28
bone	25/26
breast	28/33
central nervous system	55/56
cervix	4/4
colorectal	16/17
esophagus	13/13
fibroblast	1/1
gastric	15/16
kidney	21/21
liver	17/20
lung	69/75
lymphocyte	16/16
ovary	26/26
pancreas	24/24
peripheral nervous system	15/16
plasma cell	13/15
prostate	0/1
skin	24/24
soft tissue	9/9
thyroid	2/2
upper aerodigestive	22/22
urinary tract	28/29
uterus	3/5

Expression Distribution

nucleolar ribonuclease P complex
ribonuclease P RNA binding
multimeric ribonuclease P complex
ribonuclease P activity
tRNA 5-leader removal
tRNA 5-end processing
ncRNA 5-end processing
RNA 5-end processing
RNA phosphodiester bond hydrolysis, endonucleolytic
tRNA processing
RNA phosphodiester bond hydrolysis
tRNA metabolic process
rRNA processing
rRNA metabolic process
nucleic acid phosphodiester bond hydrolysis
ribosome biogenesis
ncRNA processing
ribonucleoprotein complex biogenesis
ncRNA metabolic process
RNA processing
RNA metabolic process
gene expression