SLC27A1

Gene Information

Official Symbol: SLC27A1
Official Name: solute carrier family 27 member 1
Aliases and Previous Symbols: N/A
Entrez ID: 376497
UniProt: Q6PCB7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Involved in translocation of long-chain fatty acids (LFCA) across the plasma membrane. The LFCA import appears to be hormone-regulated in a tissue-specific manner. In adipocytes, but not myocytes, insulin induces a rapid translocation of FATP1 from intracellular compartments to the plasma membrane, paralleled by increased LFCA uptake. May act directly as a bona fide transporter, or alternatively, in a cytoplasmic or membrane- associated multimeric protein complex to trap and draw fatty acids towards accumulation. Plays a pivotal role in regulating available LFCA substrates from exogenous sources in tissues undergoing high levels of beta-oxidation or triglyceride synthesis. May be involved in regulation of cholesterol metabolism. Has acyl-CoA ligase activity for long-chain and very-long-chain fatty acids (By similarity). {ECO:0000250, ECO:0000269|PubMed:12235169}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 5786
Expression level (log2 read counts): 4.65

Expression Distribution

medium-chain fatty acid transport
fatty acid transmembrane transporter activity
phosphatidylserine biosynthetic process
negative regulation of phospholipid biosynthetic process
cardiolipin biosynthetic process
adiponectin-activated signaling pathway
phosphatidylglycerol biosynthetic process
very long-chain fatty acid-CoA ligase activity
negative regulation of phospholipid metabolic process
long-chain fatty acid import into cell
lipid import into cell
positive regulation of heat generation
long-chain fatty acid transporter activity
positive regulation of triglyceride biosynthetic process
long-chain fatty acid-CoA ligase activity
regulation of heat generation
cardiolipin metabolic process
phosphatidylethanolamine biosynthetic process
regulation of triglyceride biosynthetic process
regulation of phospholipid biosynthetic process
positive regulation of triglyceride metabolic process
phosphatidylethanolamine metabolic process
phosphatidylglycerol metabolic process
phosphatidylserine metabolic process
phosphatidylcholine biosynthetic process
regulation of triglyceride metabolic process
phosphatidic acid biosynthetic process
phosphatidic acid metabolic process
cellular modified amino acid biosynthetic process
response to cold
negative regulation of lipid biosynthetic process
long-chain fatty acid transport
nucleotide binding
fatty acid transport
phosphatidylcholine metabolic process
positive regulation of lipid biosynthetic process
negative regulation of lipid metabolic process
regulation of phospholipid metabolic process
phosphatidylinositol biosynthetic process
long-chain fatty acid metabolic process