SOAT1

Entrez Summary: The protein encoded by this gene belongs to the acyltransferase family. It is located in the endoplasmic reticulum, and catalyzes the formation of fatty acid-cholesterol esters. This gene has been implicated in the formation of beta-amyloid and atherosclerotic plaques by controlling the equilibrium between free cholesterol and cytoplasmic cholesteryl esters. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2011].
UniProt Summary: Catalyzes the formation of fatty acid-cholesterol esters, which are less soluble in membranes than cholesterol. Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
LY2090314 0.003μM R08 exp499	-1.99
Ribavirin 10μM R01 exp52	-1.99

sterol O-acyltransferase activity
cholesterol storage
cholesterol O-acyltransferase activity
positive regulation of amyloid precursor protein biosynthetic process
cholesterol esterification
sterol esterification
steroid esterification
macrophage derived foam cell differentiation
foam cell differentiation
very-low-density lipoprotein particle assembly
regulation of amyloid precursor protein biosynthetic process
positive regulation of glycoprotein biosynthetic process
fatty-acyl-CoA binding
positive regulation of glycoprotein metabolic process
cholesterol efflux
low-density lipoprotein particle clearance
plasma lipoprotein particle assembly
lipid storage
protein-lipid complex assembly
plasma lipoprotein particle clearance
regulation of glycoprotein biosynthetic process
plasma lipoprotein particle organization
regulation of glycoprotein metabolic process
protein-lipid complex subunit organization
cholesterol binding
cholesterol transport
sterol transport
regulation of plasma lipoprotein particle levels
cholesterol homeostasis
sterol homeostasis
cholesterol metabolic process
secondary alcohol metabolic process
lipid homeostasis
sterol metabolic process
organic hydroxy compound transport
maintenance of location
lipid modification
steroid metabolic process
lipid transport
alcohol metabolic process