ST6GALNAC6

Entrez Summary: N/A
UniProt Summary: Alpha-2,6-sialyltransferase involved in the synthesis of alpha-series gangliosides. Has activity toward GD1a, GT1b and GM1b. Has no activity toward glycoproteins. Responsible for the biosynthesis of DSGG (disialylgalactosylgloboside) from MSGG (monosialylgalactosylgloboside) in normal and malignant kidney. Participates in the synthesis of disialyl Lewis a (Le(a)). {ECO:0000269|PubMed:12668675, ECO:0000269|PubMed:17123352}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity
ganglioside biosynthetic process
sialyltransferase activity
glycosylceramide metabolic process
oligosaccharide biosynthetic process
ganglioside metabolic process
sialylation
glycosphingolipid biosynthetic process
ceramide biosynthetic process
oligosaccharide metabolic process
glycosphingolipid metabolic process
glycolipid biosynthetic process
cell-cell recognition
ceramide metabolic process
sphingolipid biosynthetic process
glycolipid metabolic process
liposaccharide metabolic process
carbohydrate biosynthetic process
membrane lipid biosynthetic process
sphingolipid metabolic process
membrane lipid metabolic process
cell recognition
macromolecule glycosylation
protein glycosylation
glycosylation
glycoprotein biosynthetic process
glycoprotein metabolic process
carbohydrate metabolic process
amide biosynthetic process
lipid biosynthetic process
Golgi membrane
carbohydrate derivative biosynthetic process
cellular amide metabolic process
cellular lipid metabolic process
carbohydrate derivative metabolic process
lipid metabolic process
organonitrogen compound biosynthetic process
cellular nitrogen compound biosynthetic process
cellular macromolecule biosynthetic process
macromolecule biosynthetic process