SULF1

Gene Information

Official Symbol: SULF1
Official Name: sulfatase 1
Aliases and Previous Symbols: N/A
Entrez ID: 23213
UniProt: Q8IWU6
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an extracellular heparan sulfate endosulfatase. The encoded enzyme selectively removes 6-O-sulfate groups from heparan sulfate chains of heparan sulfate proteoglycans (HSPGs). The enzyme is secreted through the Golgi and is subsequently localized to the cell surface. The expression of this gene may be down-regulated in several types of cancer, including hepatocellular (HCC), ovarian and breast cancers. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013].
UniProt Summary: Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin. Diminishes HSPG (heparan sulfate proteoglycans) sulfation, inhibits signaling by heparin-dependent growth factors, diminishes proliferation, and facilitates apoptosis in response to exogenous stimulation.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 3242
Expression level (log2 read counts): 0.96

Expression Distribution

DUF3740
Sulfatase
Phosphodiest

esophagus smooth muscle contraction
N-acetylglucosamine-6-sulfatase activity
negative regulation of prostatic bud formation
gastro-intestinal system smooth muscle contraction
regulation of prostatic bud formation
glial cell-derived neurotrophic factor receptor signaling pathway
glomerular basement membrane development
glomerular filtration
renal filtration
arylsulfatase activity
negative regulation of fibroblast growth factor receptor signaling pathway
negative regulation of morphogenesis of an epithelium
glycosaminoglycan binding
negative regulation of embryonic development
innervation
positive regulation of vascular endothelial growth factor production
regulation of fibroblast growth factor receptor signaling pathway
regulation of vascular endothelial growth factor production
positive regulation of BMP signaling pathway
negative regulation of animal organ morphogenesis
heparan sulfate proteoglycan metabolic process
regulation of animal organ formation
Golgi stack
negative regulation of endothelial cell proliferation
chondrocyte development
glomerulus development
smooth muscle contraction
negative regulation of reproductive process
regulation of morphogenesis of a branching structure
vascular endothelial growth factor receptor signaling pathway
nerve development
chondrocyte differentiation
regulation of BMP signaling pathway
proteoglycan metabolic process
negative regulation of angiogenesis
positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
negative regulation of blood vessel morphogenesis
renal system process
negative regulation of vasculature development
negative regulation of epithelial cell proliferation