TMEM38B

Gene Information

Official Symbol: TMEM38B
Official Name: transmembrane protein 38B
Aliases and Previous Symbols: N/A
Entrez ID: 55151
UniProt: Q9NVV0
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes an intracellular monovalent cation channel that functions in maintenance of intracellular calcium release. Mutations in this gene may be associated with autosomal recessive osteogenesis. [provided by RefSeq, Oct 2012].
UniProt Summary: Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. {ECO:0000250|UniProtKB:Q9DAV9}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13422
Expression level (log2 read counts): 3.98

Expression Distribution

Screen	Score
BRD2 inhibitor II 20μM R07 exp341	1.86
Metformin 100 to 150μM on day4 R04 exp170	1.9

secretion by lung epithelial cell involved in lung growth
extracellular matrix constituent secretion
lung growth
release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
release of sequestered calcium ion into cytosol by endoplasmic reticulum
cellular response to caffeine
cellular response to purine-containing compound
sarcoplasmic reticulum calcium ion transport
response to diuretic
response to caffeine
regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion
lung epithelial cell differentiation
lung cell differentiation
regulation of cardiac muscle contraction by calcium ion signaling
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
potassium channel activity
lung epithelium development
sarcoplasmic reticulum membrane
cellular response to alkaloid
lung alveolus development
bone mineralization
endoplasmic reticulum organization
release of sequestered calcium ion into cytosol
negative regulation of sequestering of calcium ion
calcium ion transmembrane import into cytosol
calcium ion transport into cytosol
regulation of cardiac muscle contraction
regulation of release of sequestered calcium ion into cytosol
cytosolic calcium ion transport
regulation of striated muscle contraction
biomineral tissue development
biomineralization
organ growth
regulation of calcium ion transport into cytosol
response to alkaloid
regulation of sequestering of calcium ion
calcium-mediated signaling
regulation of calcium ion transmembrane transport
response to purine-containing compound
potassium ion transmembrane transport