TMPRSS4

Gene Information
  • Official Symbol: TMPRSS4
  • Official Name: transmembrane serine protease 4
  • Aliases and Previous Symbols: N/A
  • Entrez ID: 56649
  • UniProt: Q9NRS4
  • Interactions: BioGRID
  • PubMed articles: Open PubMed
  • OMIM: Open OMIM
Function Summary
  • Entrez Summary: This gene encodes a member of the serine protease family. Serine proteases are known to be involved in a variety of biological processes, whose malfunction often leads to human diseases and disorders. This gene was identified as a gene overexpressed in pancreatic carcinoma. The encoded protein is membrane bound with a N-terminal anchor sequence and a glycosylated extracellular region containing the serine protease domain. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
  • UniProt Summary: Probable protease. Seems to be capable of activating ENaC (By similarity). {ECO:0000250}.

Pfam Domains GO Terms


CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Essentiality in NALM6
  • Essentiality Rank: 10190
  • Expression level (log2 read counts): 3.05

Expression Distribution

  • Last modified: 2025/12/10 20:19
  • by 127.0.0.1