TNNI3K

Entrez Summary: This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012].
UniProt Summary: May play a role in cardiac physiology. {ECO:0000303|PubMed:12721663}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
IU1-C 25μM R04 exp183	-1.77
Rapamycin 0.001μM R08 exp429	1.84

troponin I binding
bundle of His cell to Purkinje myocyte communication
cell communication involved in cardiac conduction
regulation of cardiac conduction
regulation of cardiac muscle contraction
regulation of striated muscle contraction
cardiac conduction
regulation of heart rate
multicellular organismal signaling
regulation of muscle contraction
protein C-terminus binding
regulation of muscle system process
protein kinase activity
regulation of heart contraction
regulation of blood circulation
protein serine/threonine kinase activity
regulation of system process
protein phosphorylation
phosphorylation
ATP binding