TP73

Gene Information

Official Symbol: TP73
Official Name: tumor protein p73
Aliases and Previous Symbols: N/A
Entrez ID: 7161
UniProt: O15350
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011].
UniProt Summary: N/A

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 7972
Expression level (log2 read counts): 1.8

Expression Distribution

P53 tetramer
SAM 2
P53

MDM2/MDM4 family protein binding
negative regulation of cardiac muscle cell proliferation
positive regulation of oligodendrocyte differentiation
negative regulation of cardiac muscle tissue growth
negative regulation of heart growth
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
negative regulation of organ growth
negative regulation of cardiac muscle tissue development
mismatch repair
positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
regulation of oligodendrocyte differentiation
regulation of cardiac muscle cell proliferation
positive regulation of glial cell differentiation
regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway
negative regulation of striated muscle tissue development
negative regulation of muscle organ development
intrinsic apoptotic signaling pathway by p53 class mediator
negative regulation of muscle tissue development
regulation of cardiac muscle tissue growth
positive regulation of establishment of protein localization to mitochondrion
regulation of heart growth
p53 binding
positive regulation of gliogenesis
regulation of glial cell differentiation
intrinsic apoptotic signaling pathway in response to DNA damage
regulation of mitochondrial membrane permeability
regulation of hematopoietic stem cell differentiation
regulation of establishment of protein localization to mitochondrion
regulation of cardiac muscle tissue development
positive regulation of cell cycle arrest
regulation of membrane permeability
regulation of hematopoietic progenitor cell differentiation
regulation of organ growth
negative regulation of developmental growth
regulation of cell cycle arrest
chromatin
positive regulation of mitochondrion organization
regulation of gliogenesis