TRAT1

Gene Information

Official Symbol: TRAT1
Official Name: T cell receptor associated transmembrane adaptor 1
Aliases and Previous Symbols: N/A
Entrez ID: 50852
UniProt: Q6PIZ9
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Stabilizes the TCR (T-cell antigen receptor)/CD3 complex at the surface of T-cells. {ECO:0000269|PubMed:11390434}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18031
Expression level (log2 read counts): -7.68

Expression Distribution

Screen	Score
Atovaquone 15μM R08 exp451	-1.95
Hydroxychloroquine 30μM R08 exp490	-1.87
Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307	1.74

negative regulation of receptor recycling
transmembrane receptor protein tyrosine kinase adaptor activity
positive regulation of T cell receptor signaling pathway
positive regulation of antigen receptor-mediated signaling pathway
regulation of receptor recycling
regulation of T cell receptor signaling pathway
positive regulation of calcium-mediated signaling
cellular defense response
regulation of antigen receptor-mediated signaling pathway
regulation of calcium-mediated signaling
T cell receptor complex
positive regulation of protein kinase B signaling
T cell receptor signaling pathway
regulation of protein kinase B signaling
antigen receptor-mediated signaling pathway
immune response-activating cell surface receptor signaling pathway
immune response-regulating cell surface receptor signaling pathway
negative regulation of transport
transmembrane receptor protein tyrosine kinase signaling pathway
immune response-activating signal transduction
immune response-regulating signaling pathway
adaptive immune response
activation of immune response
enzyme linked receptor protein signaling pathway
positive regulation of immune response
positive regulation of intracellular signal transduction
positive regulation of immune system process
regulation of immune response
defense response
negative regulation of signaling
integral component of plasma membrane
regulation of immune system process
positive regulation of signal transduction
positive regulation of cell communication
positive regulation of signaling
regulation of intracellular signal transduction
regulation of transport
immune response