TRIB3

Gene Information

Official Symbol: TRIB3
Official Name: tribbles pseudokinase 3
Aliases and Previous Symbols: N/A
Entrez ID: 57761
UniProt: Q96RU7
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activity. Inhibits the transcriptional activity of DDIT3/CHOP and is involved in DDIT3/CHOP-dependent cell death during ER stress. Can inhibit APOBEC3A editing of nuclear DNA. {ECO:0000269|PubMed:12736262, ECO:0000269|PubMed:15299019, ECO:0000269|PubMed:15775988, ECO:0000269|PubMed:15781252, ECO:0000269|PubMed:22977230}.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 13631
Expression level (log2 read counts): 5.48

Expression Distribution

Screen	Score
Erlotinib 10μM R05 exp216	-2.64
LB-100 2μM R05 exp210	-1.72

Pkinase Tyr
Pkinase

ubiquitin-protein transferase regulator activity
mitogen-activated protein kinase kinase binding
negative regulation of fatty acid biosynthetic process
negative regulation of fatty acid metabolic process
protein kinase inhibitor activity
positive regulation of ubiquitin-protein transferase activity
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
regulation of fatty acid biosynthetic process
negative regulation of fat cell differentiation
negative regulation of protein kinase B signaling
negative regulation of lipid biosynthetic process
regulation of ubiquitin-protein transferase activity
regulation of glucose transmembrane transport
kinase activity
positive regulation of proteasomal ubiquitin-dependent protein catabolic process
negative regulation of lipid metabolic process
regulation of fatty acid metabolic process
negative regulation of small molecule metabolic process
positive regulation of protein binding
positive regulation of ubiquitin-dependent protein catabolic process
positive regulation of proteasomal protein catabolic process
positive regulation of protein ubiquitination
positive regulation of proteolysis involved in cellular protein catabolic process
regulation of fat cell differentiation
regulation of proteasomal ubiquitin-dependent protein catabolic process
positive regulation of protein modification by small protein conjugation or removal
positive regulation of cellular protein catabolic process
intrinsic apoptotic signaling pathway
regulation of ubiquitin-dependent protein catabolic process
cellular response to insulin stimulus
regulation of cellular ketone metabolic process
positive regulation of binding
regulation of proteasomal protein catabolic process
regulation of lipid biosynthetic process
regulation of protein ubiquitination
positive regulation of protein catabolic process
regulation of proteolysis involved in cellular protein catabolic process
regulation of protein binding
regulation of protein kinase B signaling
negative regulation of protein kinase activity