TUSC2

Gene Information

Official Symbol: TUSC2
Official Name: tumor suppressor 2, mitochondrial calcium regulator
Aliases and Previous Symbols: N/A
Entrez ID: 11334
UniProt: O75896
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 18075
Expression level (log2 read counts): 4.84

Expression Distribution

Screen	Score
Bortezomib 0.005μM R00 exp6	-1.73
MS023 2μM R03 exp134	-1.7

interleukin-15 production
response to defense-related host reactive oxygen species production
response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction
chemokine (C-C motif) ligand 5 production
neutrophil mediated killing of gram-negative bacterium
neutrophil mediated killing of bacterium
neutrophil mediated killing of symbiont cell
response to immune response of other organism involved in symbiotic interaction
response to host immune response
neutrophil mediated cytotoxicity
response to host defenses
response to defenses of other organism involved in symbiotic interaction
response to host
natural killer cell differentiation
killing by host of symbiont cells
chemokine production
disruption by host of symbiont cells
killing of cells in other organism involved in symbiotic interaction
disruption of cells of other organism involved in symbiotic interaction
negative regulation of interleukin-17 production
regulation of interleukin-17 production
positive regulation of interleukin-10 production
leukocyte mediated cytotoxicity
killing of cells of other organism
disruption of cells of other organism
regulation of interleukin-10 production
natural killer cell activation
regulation of mitochondrial membrane potential
modification by host of symbiont morphology or physiology
interaction with symbiont
defense response to Gram-negative bacterium
cell killing
modification of morphology or physiology of other organism involved in symbiotic interaction
cytokine production
modification of morphology or physiology of other organism
interaction with host
cell maturation
regulation of reactive oxygen species metabolic process
lymphocyte differentiation
developmental maturation