UBP1

Entrez Summary: N/A
UniProt Summary: Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box. {ECO:0000250, ECO:0000269|PubMed:10644752, ECO:0000269|PubMed:2006421, ECO:0000269|PubMed:8114710}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
UM131593 0.2μM R03 exp106	1.72
THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412	1.78
CR131-b 0.005μM R08 exp474	1.86
Nutlin-3A 1.6μM R06 exp294	1.87
Campthothecin 0.001μM R06 exp270	1.93
BVD-523 15μM R02 exp67	1.94
Nicotine 3000μM R08 exp510	1.94
Ethambutol 25μM R08 exp481	2
THZ531 0.11 to 0.175μM on day4 R07 exp413	2.06
RO-3307 4.7μM R02 exp80	3.58

Global Fraction of Cell Lines Where Essential: 0/726

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/25
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/15
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/14
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/7
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

viral genome replication
viral life cycle
transcription corepressor activity
angiogenesis
blood vessel morphogenesis
sequence-specific DNA binding
blood vessel development
vasculature development
cardiovascular system development
tube morphogenesis
DNA-binding transcription factor activity
viral process
symbiotic process
interspecies interaction between organisms
tube development
circulatory system development
anatomical structure formation involved in morphogenesis
negative regulation of transcription, DNA-templated
negative regulation of nucleic acid-templated transcription
negative regulation of RNA biosynthetic process
negative regulation of RNA metabolic process
negative regulation of cellular macromolecule biosynthetic process
negative regulation of nucleobase-containing compound metabolic process
DNA binding
negative regulation of macromolecule biosynthetic process
negative regulation of cellular biosynthetic process
negative regulation of biosynthetic process
DNA-binding transcription factor activity, RNA polymerase II-specific
negative regulation of gene expression