UPP2

Gene Information

Official Symbol: UPP2
Official Name: uridine phosphorylase 2
Aliases and Previous Symbols: N/A
Entrez ID: 151531
UniProt: O95045
Interactions: BioGRID
PubMed articles: Open PubMed
OMIM: Open OMIM

Function Summary

Entrez Summary: N/A
UniProt Summary: Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. Shows substrate specificity and accept uridine, deoxyuridine, and thymidine as well as the two pyrimidine nucleoside analogs 5-fluorouridine and 5-fluoro-2(')-deoxyuridine as substrates.

Pfam Domains GO Terms

CRISPR Data

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Essentiality in NALM6

Essentiality Rank: 16946
Expression level (log2 read counts): -1.16

Expression Distribution

uridine phosphorylase activity
uridine metabolic process
type III intermediate filament
UMP salvage
pyrimidine nucleotide salvage
pyrimidine ribonucleotide salvage
pyrimidine ribonucleoside monophosphate metabolic process
UMP metabolic process
UMP biosynthetic process
pyrimidine ribonucleoside monophosphate biosynthetic process
pyrimidine nucleoside salvage
pyrimidine-containing compound salvage
pyrimidine ribonucleoside metabolic process
nucleotide salvage
pyrimidine nucleoside monophosphate biosynthetic process
nucleoside salvage
pyrimidine nucleoside biosynthetic process
pyrimidine nucleoside monophosphate metabolic process
pyrimidine ribonucleotide biosynthetic process
pyrimidine nucleoside catabolic process
pyrimidine ribonucleotide metabolic process
ribonucleoside monophosphate biosynthetic process
nucleoside catabolic process
cellular metabolic compound salvage
pyrimidine nucleoside metabolic process
nucleoside biosynthetic process
glycosyl compound biosynthetic process
nucleoside monophosphate biosynthetic process
pyrimidine-containing compound catabolic process
glycosyl compound catabolic process
pyrimidine nucleotide biosynthetic process
nucleobase-containing small molecule catabolic process
ribonucleoside monophosphate metabolic process
pyrimidine-containing compound biosynthetic process
pyrimidine nucleotide metabolic process
nucleotide catabolic process
nucleoside phosphate catabolic process
nucleoside monophosphate metabolic process
ribonucleoside metabolic process
pyrimidine-containing compound metabolic process