UQCRB

Entrez Summary: This gene encodes a subunit of the ubiquinol-cytochrome c oxidoreductase complex, which consists of one mitochondrial-encoded and 10 nuclear-encoded subunits. The protein encoded by this gene binds ubiquinone and participates in the transfer of electrons when ubiquinone is bound. This protein plays an important role in hypoxia-induced angiogenesis through mitochondrial reactive oxygen species-mediated signaling. Mutations in this gene are associated with mitochondrial complex III deficiency. Alternatively spliced transcript variants have been found for this gene. Related pseudogenes have been identified on chromosomes 1, 5 and X. [provided by RefSeq, Dec 2011].
UniProt Summary: This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This component is involved in redox-linked proton pumping.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
GSK626616 14μM R08 exp485	1.79
CR131-b 0.005μM R08 exp474	1.83
Genistein 15μM R07 exp360	1.92
Ethanol 0.01 R05 exp234	1.98
Ammonium tetrathiomolybdate 10μM R08 exp448	2.31

Global Fraction of Cell Lines Where Essential: 12/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	1/26
breast	2/33
central nervous system	1/56
cervix	1/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	1/21
liver	0/20
lung	1/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	1/15
prostate	0/1
skin	1/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	1/29
uterus	0/5

Expression Distribution

mitochondrial respiratory chain complex III assembly
respiratory chain complex III assembly
ubiquinol-cytochrome-c reductase activity
mitochondrial respiratory chain complex III
mitochondrial electron transport, ubiquinol to cytochrome c
mitochondrial respirasome
cytochrome complex assembly
aerobic respiration
mitochondrial ATP synthesis coupled electron transport
ATP synthesis coupled electron transport
mitochondrial respiratory chain complex assembly
respiratory electron transport chain
oxidative phosphorylation
cellular respiration
electron transport chain
ATP metabolic process
energy derivation by oxidation of organic compounds
mitochondrial inner membrane
generation of precursor metabolites and energy
mitochondrion organization
cellular protein-containing complex assembly
oxidation-reduction process
phosphorylation
protein-containing complex assembly
protein-containing complex subunit organization