USP30

Entrez Summary: N/A
UniProt Summary: Deubiquitinating enzyme tethered to the mitochondrial outer membrane that acts as a key inhibitor of mitophagy by counteracting the action of parkin (PRKN): hydrolyzes ubiquitin attached by parkin on target proteins, such as RHOT1/MIRO1 and TOMM20, thereby blocking parkin's ability to drive mitophagy (PubMed:18287522, PubMed:24896179, PubMed:25527291, PubMed:25621951). Preferentially cleaves 'Lys-6'- and 'Lys-11'- linked polyubiquitin chains, 2 types of linkage that participate to mitophagic signaling (PubMed:25621951). Does not cleave efficiently polyubiquitin phosphorylated at 'Ser-65' (PubMed:25527291). Acts as negative regulator of mitochondrial fusion by mediating deubiquitination of MFN1 and MFN2 (By similarity). {ECO:0000250|UniProtKB:Q3UN04, ECO:0000269|PubMed:18287522, ECO:0000269|PubMed:24896179, ECO:0000269|PubMed:25527291, ECO:0000269|PubMed:25621951}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

protein K6-linked deubiquitination
negative regulation of mitophagy
negative regulation of autophagy of mitochondrion
protein K11-linked deubiquitination
regulation of mitophagy
mitochondrial fusion
negative regulation of macroautophagy
mitochondrion disassembly
autophagy of mitochondrion
regulation of autophagy of mitochondrion
negative regulation of mitochondrion organization
thiol-dependent ubiquitinyl hydrolase activity
organelle disassembly
negative regulation of autophagy
cysteine-type endopeptidase activity
organelle fusion
thiol-dependent ubiquitin-specific protease activity
mitochondrial outer membrane
regulation of macroautophagy
regulation of mitochondrion organization
negative regulation of cellular catabolic process
process utilizing autophagic mechanism
autophagy
protein deubiquitination
protein modification by small protein removal
negative regulation of catabolic process
regulation of autophagy
negative regulation of organelle organization
cellular component disassembly
mitochondrion organization
ubiquitin-dependent protein catabolic process
modification-dependent protein catabolic process
modification-dependent macromolecule catabolic process
proteolysis involved in cellular protein catabolic process
cellular protein catabolic process
protein catabolic process
negative regulation of cellular component organization
regulation of cellular catabolic process
cellular macromolecule catabolic process
protein modification by small protein conjugation or removal