USP53

Entrez Summary: N/A
UniProt Summary: Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (By similarity). Has no peptidase activity (PubMed:14715245). {ECO:0000250|UniProtKB:P15975, ECO:0000269|PubMed:14715245}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Screen	Score
Staurosporine 0.02μM R08 exp524	1.75
Menadione 5μM R06 exp292	1.87

response to auditory stimulus
neuron apoptotic process
neuron death
thiol-dependent ubiquitinyl hydrolase activity
action potential
bicellular tight junction
sensory perception of sound
sensory perception of mechanical stimulus
cell-cell junction
response to mechanical stimulus
protein deubiquitination
protein modification by small protein removal
regulation of membrane potential
cellular component
apoptotic process
sensory perception
protein modification by small protein conjugation or removal
programmed cell death
cell death
response to abiotic stimulus
proteolysis
nervous system process
system process