VPS13C

Entrez Summary: This gene encodes a member of the vacuolar protein sorting-associated 13 gene family. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2010].
UniProt Summary: Necessary for proper mitochondrial function and maintenance of mitochondrial transmembrane potential. Involved in the regulation of PINK1/PRKN-mediated mitophagy in response to mitochondrial depolarization. {ECO:0000269|PubMed:26942284}.

Pfam Domains GO Terms

Compound Hit Most Correlated Genes in Chemogenomics Tissues where Essential in the Avana Dataset (DepMap 20Q1)

Screen	Score
Cadmium 60μM R08 exp462	-2.15
DABN 2μM R00 exp16	-1.78
42°C R08 exp539	-1.75
AICAR 240μM R05 exp211	-1.73
Olaparib 4μM R08 exp512	1.72
Betulinic acid 10 to 15μM on day4 R05 exp222	1.89
Vemurafenib 6.6μM R02 exp89	1.9
Trichostatin-A 0.06μM R07 exp415	2.07

Global Fraction of Cell Lines Where Essential: 0/739

Tissue	Fraction Of Cell Lines Where Essential
1290807.0	0/1
909776.0	0/1
bile duct	0/28
blood	0/28
bone	0/26
breast	0/33
central nervous system	0/56
cervix	0/4
colorectal	0/17
esophagus	0/13
fibroblast	0/1
gastric	0/16
kidney	0/21
liver	0/20
lung	0/75
lymphocyte	0/16
ovary	0/26
pancreas	0/24
peripheral nervous system	0/16
plasma cell	0/15
prostate	0/1
skin	0/24
soft tissue	0/9
thyroid	0/2
upper aerodigestive	0/22
urinary tract	0/29
uterus	0/5

Expression Distribution

Chorein N
DUF1162

negative regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
regulation of parkin-mediated stimulation of mitophagy in response to mitochondrial depolarization
protein retention in Golgi apparatus
regulation of mitophagy
Golgi to endosome transport
protein localization to Golgi apparatus
protein targeting to vacuole
regulation of autophagy of mitochondrion
establishment of protein localization to vacuole
protein localization to vacuole
extrinsic component of membrane
maintenance of protein location in cell
maintenance of location in cell
post-Golgi vesicle-mediated transport
maintenance of protein location
vacuolar transport
cytosolic transport
mitochondrial outer membrane
maintenance of location
regulation of macroautophagy
regulation of mitochondrion organization
regulation of autophagy
protein targeting
Golgi vesicle transport
establishment of protein localization to organelle
mitochondrion organization
protein localization to organelle
regulation of cellular response to stress
regulation of cellular catabolic process
intracellular protein transport
regulation of catabolic process
regulation of organelle organization
regulation of response to stress
protein transport
intracellular transport
peptide transport
amide transport
cellular protein localization
cellular macromolecule localization
establishment of protein localization